When nonprofit organizations make significant changes in mission, there are many issues of organizational structure and culture that must be re-examined and re-aligned. As the second segment in the case of Casa de Esperanza illustrates, there are many human issues that must be navigated by leaders making such changes. Case B illustrates the challenges that must be confronted as leaders embrace the agency’s identity as a community-based Latina organization, rather than a government-funded domestic violence organization. The case describes the management planning and implementation processes, including changes in leadership, programming, and operations. Staff responses to these changes are also stressed, revealing the very human elements of organizational change.