Carotid intima–media thickness and markers of brain health in a biracial middle-aged cohort: CARDIA brain MRI sub-study

Pavla Cermakova, Jie Ding, Osorio Meirelles, Jared Reis, Dorota Religa, Pamela J. Schreiner, David R. Jacobs, R. Nick Bryan, Lenore J. Launer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: We investigated whether carotid intima–media thickness is associated with measures of cerebral blood flow (CBF), white matter hyperintensities, and brain volume in a biracial cohort of middle-aged individuals. Methods: We performed a cross-sectional cohort study based on data from a multicenter, population-based study Coronary Artery Risk Development in Young Adults. Using linear and logistic regression, we estimated the association of the composite intima–media thickness measured in three segments of carotid arteries (common carotid artery, carotid artery bulb, and internal carotid artery) with volume (cm3) and CBF (mL/100 g/min) in the total brain and gray matter as well as volume of white matter hyperintensities (cm3). Results: In the analysis, 461 participants (54% women, 34% African Americans) were included. Greater intima–media thickness was associated with lower CBF in gray matter (β=–1.36; p = .04) and total brain (β=–1.26; p = .04), adjusting for age, sex, race, education, and total brain volume. The associations became statistically nonsignificant after further controlling for cardiovascular risk factors. Intima–media thickness was not associated with volumes of total brain, gray matter, and white matter hyperintensities. Conclusions: This study suggests that lower CBF in middle age is associated with markers of atherosclerosis in the carotid arteries. This association may reflect early long-term exposure to traditional cardiovascular risk factors. Early intervention on atherosclerotic risk factors may modulate the trajectory of CBF as people age and develop brain pathology.

Original languageEnglish (US)
Pages (from-to)380-386
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume75
Issue number2
DOIs
StatePublished - Feb 1 2020

Bibliographical note

Funding Information:
and Sports of the Czech Republic (P.C.) and PRIMUS (247066) conducted at Charles University (P.C.). CARDIA is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201300025C and HHSN268201300026C), Northwestern University (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser Foundation Research Institute (HHSN268201300029C), and Johns Hopkins University School of Medicine (HHSN268200900041C). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). This manuscript has been reviewed by CARDIA for scientific content.

Funding Information:
This study was supported by the Swedish Research Council (523-2012-2291 to P.C. and D.R.), the Alzheimer Foundation?Czech Republic (P.C.), project ?Sustainability for the National Institute of Mental Health? (grant LO1611), with a financial support from the Ministry of Education, Youth and Sports of the Czech Republic (P.C.) and PRIMUS (247066) conducted at Charles University (P.C.). CARDIA is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201300025C and HHSN268201300026C), Northwestern University (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser Foundation Research Institute (HHSN268201300029C), and Johns Hopkins University School of Medicine (HHSN268200900041C). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). This manuscript has been reviewed by CARDIA for scientific content.

Funding Information:
This study was supported by the Swedish Research Council (523-2012-2291 to P.C. and D.R.), the Alzheimer Foundation–Czech Republic (P.C.), project “Sustainability for the National Institute of Mental Health” (grant LO1611), with a financial support from the Ministry of Education, Youth

Publisher Copyright:
© 2020 Oxford University Press. All rights reserved.

Keywords

  • Brain perfusion
  • Carotid intima–media thickness
  • Epidemiology

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