Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

Wendy Wang, Rebecca F. Gottesman, Michelle L. Meyer, Timothy M. Hughes, Kevin J. Sullivan, Dean F. Wong, Kamakshi Lakshminarayan, Pamela L. Lutsey

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed whether carotid intima-media thickness (cIMT) is prospectively associated with amyloid-β (Aβ). 332 nondemented Atherosclerosis Risk in Communities Study participants with carotid ultrasounds (1990-1992) and PET scans (2012-2014) were studied. Participants in the highest (versus lowest) cIMT tertile had 2.17 times the odds of elevated Aβ (95% CI: 1.15-4.11), after demographic and APOE ɛ4 adjustments. An interaction with APOE ɛ4 was observed (p = 0.02). Greater cIMT was associated with elevated Aβ independent of vascular risk factors among those with ≥1 APOE ɛ4 allele, but not in noncarriers. In this cohort, higher cIMT was associated with Aβ deposition 22 years later, particularly among APOE ɛ4 carriers.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalJournal of Alzheimer's Disease
Volume88
Issue number1
DOIs
StatePublished - 2022

Bibliographical note

Funding Information:
The ARIC Study is carried out as a collaborative study supported by NHLBI contracts (HHSN26820 1700001I, HHSN268201700002I, HHSN2682017 00003I, HHSN268201700005I, HHSN2682017000 04I). Neurocognitive data is collected by U01 2U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917 from the NIH (NHLBI, NINDS, NIA and NIDCD). Brain MRI examinations are funded by the NHLBI (R01-HL70825). The ARIC-PET study is funded by the NIA (R01AG040282). Avid Radiopharmaceuticals provided the florbetapir isotope for the study but had no role in the study design or interpretation of results. This work was also supported by the NIGMS [T32GM132063 (WW)] and the NHLBI [K24HL159246 (PLL)]. The authors thank ARIC study staff and participants for their important contributions.

Publisher Copyright:
© 2022-IOS Press. All rights reserved.

Keywords

  • Alzheimer's disease
  • amyloid-β
  • carotid intima-media thickness
  • carotid ultrasound
  • florbetapir PET
  • Carotid Intima-Media Thickness
  • Humans
  • Risk Factors
  • Positron-Emission Tomography
  • Carotid Arteries/diagnostic imaging
  • Carotid Artery Diseases/diagnostic imaging
  • Amyloid beta-Peptides
  • Apolipoproteins E

PubMed: MeSH publication types

  • Letter
  • Research Support, N.I.H., Extramural

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