Carotenoids improve the development of cerebral cortical networks in formula-fed infant macaques

Oscar Miranda-Dominguez, Julian S.B. Ramirez, A. J. Mitchell, Anders Perrone, Eric Earl, Sam Carpenter, Eric Feczko, Alice Graham, Sookyoung Jeon, Neal J. Cohen, Laurie Renner, Martha Neuringer, Matthew J. Kuchan, John W. Erdman, Damien Fair

Research output: Contribution to journalArticlepeer-review

Abstract

Nutrition during the first years of life has a significant impact on brain development. This study characterized differences in brain maturation from birth to 6 months of life in infant macaques fed formulas differing in content of lutein, β-carotene, and other carotenoids using Magnetic Resonance Imaging to measure functional connectivity. We observed differences in functional connectivity based on the interaction of diet, age and brain networks. Post hoc analysis revealed significant diet-specific differences between insular-opercular and somatomotor networks at 2 months of age, dorsal attention and somatomotor at 4 months of age, and within somatomotor and between somatomotor-visual and auditory-dorsal attention networks at 6 months of age. Overall, we found a larger divergence in connectivity from the breastfeeding group in infant macaques fed formula containing no supplemental carotenoids in comparison to those fed formula supplemented with carotenoids. These findings suggest that carotenoid formula supplementation influences functional brain development.

Original languageEnglish (US)
Article number15220
JournalScientific reports
Volume12
Issue number1
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
This work was supported by Abbott Laboratories through the Center for Nutrition, Learning, and Memory at the University of Illinois at Urbana-Champaign (JWE, MN), NIH grant P51OD011092 (Oregon National Primate Research Center Core grant), the Tartar Trust Fellowship (Miranda-Dominguez), OHSU Parkinson Center of Oregon Pilot Grant GBNEU0408A (Miranda-Dominguez).

Publisher Copyright:
© 2022, The Author(s).

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

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