Carnosine: An endogenous neuroprotector in the ischemic brain

Serguei L. Stvolinsky; Maria L. Kukley; Dusan Dobrota; Milena Matejovicova; Ivan Tkac; Alexander A. Boldyrev

doi:10.1023/A:1006960407008

Carnosine: An endogenous neuroprotector in the ischemic brain

Serguei L. Stvolinsky, Maria L. Kukley, Dusan Dobrota, Milena Matejovicova, Ivan Tkac, Alexander A. Boldyrev

Radiology

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49 Scopus citations

Abstract

1. The biological effects of carnosine, a natural hydrophilic neuropeptide, on the reactive oxygen species (ROS) pathological generation are reviewed. 2. We describe direct antioxidant action observed in the in vitro experiments. 3. Carnosine was found to effect metabolism indirectly. These effects are reflected in ROS turnover regulation and lipid peroxidation (LPO) processes. 4. During brain ischemia carnosine acts as a neuroprotector, contributing to better cerebral blood flow restoration, electroencephalography (EEG) normalization, decreased lactate accumulation, and enyzmatic protection against ROS. 5. The data presented demonstrate that carnosine is a specific regulator of essential metabolic pathways in neurons supporting brain homeostasis under unfavorable conditions.

Original language	English (US)
Pages (from-to)	45-56
Number of pages	12
Journal	Cellular and Molecular Neurobiology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1023/A:1006960407008
State	Published - 1999

Bibliographical note

Funding Information:
This work is the result of close collaboration between four laboratories: Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia; International Biotechnological Center of Lomonosov Moscow State University, Moscow, Russia; Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia; and MR Centre, Derer Hospital, Bratislava, Slovakia. The authors thank Academician N. V. Vereshagin, Head of the Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia, and Professor V. Mezesova, Head of Department of Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia, for support and interest in these experiments. The authors also wish to thank Dr. Y. Fujita and Professor Y. Nagata, organizers of the 7th International Symposium, ‘‘New Frontiers in the Biochemistry and Biophysics on Diagnosis and Treatment of Stroke, Neurotrauma, and Other Neurological Diseases,’’ held June 27–July 1, 1995, in Kurashiki, Japan, for their invitation and assistance in this symposium. This work was supported partially by the Russian Foundation for Fundamental Research, Grant 95-04-11969 and partially by the Slovak Ministry for Education, VTP Grant 95/5195/018 and VEGA Grant 1/4176/97.

Keywords

Antioxidants
Brain
Carnosine
Carnosine- related compounds
Ischemia
Reactive oxygen species

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10.1023/A:1006960407008

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title = "Carnosine: An endogenous neuroprotector in the ischemic brain",

abstract = "1. The biological effects of carnosine, a natural hydrophilic neuropeptide, on the reactive oxygen species (ROS) pathological generation are reviewed. 2. We describe direct antioxidant action observed in the in vitro experiments. 3. Carnosine was found to effect metabolism indirectly. These effects are reflected in ROS turnover regulation and lipid peroxidation (LPO) processes. 4. During brain ischemia carnosine acts as a neuroprotector, contributing to better cerebral blood flow restoration, electroencephalography (EEG) normalization, decreased lactate accumulation, and enyzmatic protection against ROS. 5. The data presented demonstrate that carnosine is a specific regulator of essential metabolic pathways in neurons supporting brain homeostasis under unfavorable conditions.",

keywords = "Antioxidants, Brain, Carnosine, Carnosine- related compounds, Ischemia, Reactive oxygen species",

author = "Stvolinsky, {Serguei L.} and Kukley, {Maria L.} and Dusan Dobrota and Milena Matejovicova and Ivan Tkac and Boldyrev, {Alexander A.}",

note = "Funding Information: This work is the result of close collaboration between four laboratories: Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia; International Biotechnological Center of Lomonosov Moscow State University, Moscow, Russia; Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia; and MR Centre, Derer Hospital, Bratislava, Slovakia. The authors thank Academician N. V. Vereshagin, Head of the Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia, and Professor V. Mezesova, Head of Department of Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia, for support and interest in these experiments. The authors also wish to thank Dr. Y. Fujita and Professor Y. Nagata, organizers of the 7th International Symposium, {\textquoteleft}{\textquoteleft}New Frontiers in the Biochemistry and Biophysics on Diagnosis and Treatment of Stroke, Neurotrauma, and Other Neurological Diseases,{\textquoteright}{\textquoteright} held June 27–July 1, 1995, in Kurashiki, Japan, for their invitation and assistance in this symposium. This work was supported partially by the Russian Foundation for Fundamental Research, Grant 95-04-11969 and partially by the Slovak Ministry for Education, VTP Grant 95/5195/018 and VEGA Grant 1/4176/97.",

year = "1999",

doi = "10.1023/A:1006960407008",

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AU - Tkac, Ivan

AU - Boldyrev, Alexander A.

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PY - 1999

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N2 - 1. The biological effects of carnosine, a natural hydrophilic neuropeptide, on the reactive oxygen species (ROS) pathological generation are reviewed. 2. We describe direct antioxidant action observed in the in vitro experiments. 3. Carnosine was found to effect metabolism indirectly. These effects are reflected in ROS turnover regulation and lipid peroxidation (LPO) processes. 4. During brain ischemia carnosine acts as a neuroprotector, contributing to better cerebral blood flow restoration, electroencephalography (EEG) normalization, decreased lactate accumulation, and enyzmatic protection against ROS. 5. The data presented demonstrate that carnosine is a specific regulator of essential metabolic pathways in neurons supporting brain homeostasis under unfavorable conditions.

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Carnosine: An endogenous neuroprotector in the ischemic brain

Abstract

Bibliographical note

Keywords

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