Carnitine protection against adriamycin-induced cardiomyopathy in rats

Edward O. McFalls, Dennis J. Paulson, Enid F. Gilbert, Austin L. Shug

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The effects of chronic adriamycin toxicity on myocardial carnitine content and contractile function were studied in rats, along with potential protective effect of L-carnitine administration. Cardiomyopathy was induced over a 6- to 7-week period by weekly intravenous injections of adriamycin, 2 mg/kg. In vivo myocardial tissue levels of carnitine were not significantly changed by adriamycin, but plasma levels were elevated. Cardiac output was depressed in isolated perfused hearts from adriamycin-treated rats perfused with 11 mM glucose. In a second experiment, 4-week-old male rats were divided into four groups: saline-treated control, L-carnitine-treated control, saline-treated adriamycin, and L-carnitine-treated adriamycin. L-Carnitine was given intraperitoneally each day at a dose of 500 mg/kg. Myocardial histology and ultrastructure were analyzed. Cardiac performance was determined in hearts perfused with 1.2 mM palmitate and 5.5 mM glucose. Hearts from saline-treated adriamycin rats showed histopathological changes and a significantly diminished cardiac output at various preloads when compared to saline-treated controls. Daily intraperitoneal L-carnitine reduced histopathological alterations and improved cardiac performance.

Original languageEnglish (US)
Pages (from-to)497-505
Number of pages9
JournalLife Sciences
Volume38
Issue number6
DOIs
StatePublished - Feb 10 1986

Bibliographical note

Funding Information:
Thls work was supported In part by the Veterans Admlnlstratlon and by NIH grant HL-17736.

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