Objectives. The purpose of this study was to use 1,224 surveys from the Career Pathways Evaluation Program, Pharmacist Profile Survey to (1) investigate the underlying factor structure of pharmacists' practice profiles that were created using the 34 items in the survey and (2) use the resulting factors to describe the 17 different pharmacist practices listed in the survey. The overall objective was to provide future practitioners with the opportunity to make informed career choices upon review of the data and information obtained in the profiles and practices studied. Methods. Exploratory factor analysis was used to investigate the underlying factor structure of pharmacists' practice profiles. Descriptive statistics and analysis of variance were used to describe the 17 different pharmacist practices listed in the survey. Results. Six underlying factors were identified for the pharmacists' practice profiles. A description of these factors among the 17 different respondent categories revealed variation among the categories that can be useful for describing the practice categories in the Career Pathways Evaluation Program. The nature of these variations can best be described where one practice environment has a greater (or lesser) impact on a specific factor. The findings can be used to describe pharmacy career pathways that pharmacists can follow. Conclusions. There was variation among pharmacy practice types. The profiles constructed in this study could be helpful to individuals as they consider various career paths and as they choose elective coursework or experiential sites during their pharmacy education.