Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association

Sarah D. De Ferranti, Julia Steinberger, Rebecca K Ameduri, Annette Baker, Holly Gooding, Aaron S. Kelly, Michele Mietus-Snyder, Mark M. Mitsnefes, Amy L. Peterson, Julie St-Pierre, Elaine M. Urbina, Justin P. Zachariah, Ali N. Zaidi

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234 Scopus citations


This scientific statement presents considerations for clinical management regarding the assessment and risk reduction of select pediatric populations at high risk for premature cardiovascular disease, including acquired arteriosclerosis or atherosclerosis. For each topic, the evidence for accelerated acquired coronary artery disease and stroke in childhood and adolescence and the evidence for benefit of interventions in youth will be reviewed. Children and adolescents may be at higher risk for cardiovascular disease because of significant atherosclerotic or arteriosclerotic risk factors, high-risk conditions that promote atherosclerosis, or coronary artery or other cardiac or vascular abnormalities that make the individual more vulnerable to the adverse effects of traditional cardiovascular risk factors. Existing scientific statements and guidelines will be referenced when applicable, and suggestions for risk identification and reduction specific to each setting will be described. This statement is directed toward pediatric cardiologists, primary care providers, and subspecialists who provide clinical care for these young patients. The focus will be on management and justification for management, minimizing information on pathophysiology and epidemiology.

Original languageEnglish (US)
Pages (from-to)E603-E634
Issue number13
StatePublished - Mar 26 2019

Bibliographical note

Funding Information:
Sarah D. de Ferranti, MD, MPH, FAHA, Chair Julia Steinberger, MD, MS, FAHA, Co-Chair Rebecca Ameduri, MD Annette Baker, RN, MSN, CPNP Holly Gooding, MD, MSc Aaron S. Kelly, PhD, FAHA Michele Mietus-Snyder, MD Mark M. Mitsnefes, MD, MS Amy L. Peterson, MD Julie St-Pierre, MD, PhD, FAHA Elaine M. Urbina, MD, MS, FAHA Justin P. Zachariah, MD, MPH, FAHA Ali N. Zaidi, MD On behalf of the American Heart Association Athero- sclerosis, Hypertension and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Quality of Care and Outcomes Research

Publisher Copyright:
© 2019 American Heart Association, Inc.


  • AHA Scientific Statements
  • adolescence
  • cardiovascular diseases
  • pediatrics
  • risk management
  • risk reduction


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