Cardiovascular impact in patients undergoing maintenance hemodialysis: Clinical management considerations

Srisakul Chirakarnjanakorn, Sankar D. Navaneethan, Gary S. Francis, W. H Wilson Tang

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Patients undergoing maintenance hemodialysis develop both structural and functional cardiovascular abnormalities. Despite improvement of dialysis technology, cardiovascular mortality of this population remains high. The pathophysiological mechanisms of these changes are complex and not well understood. It has been postulated that several non-traditional, uremic-related risk factors, especially the long-term uremic state, which may affect the cardiovascular system. There are many cardiovascular changes that occur in chronic kidney disease including left ventricular hypertrophy, myocardial fibrosis, microvascular disease, accelerated atherosclerosis and arteriosclerosis. These structural and functional changes in patients receiving chronic dialysis make them more susceptible to myocardial ischemia. Hemodialysis itself may adversely affect the cardiovascular system due to non-physiologic fluid removal, leading to hemodynamic instability and initiation of systemic inflammation. In the past decade there has been growing awareness that pathophysiological mechanisms cause cardiovascular dysfunction in patients on chronic dialysis, and there are now pharmacological and non-pharmacological therapies that may improve the poor quality of life and high mortality rate that these patients experience.

Original languageEnglish (US)
Pages (from-to)12-23
Number of pages12
JournalInternational Journal of Cardiology
Volume232
DOIs
StatePublished - Apr 1 2017

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Renal Dialysis
Maintenance
Dialysis
Cardiovascular System
Cardiovascular Abnormalities
Mortality
Arteriosclerosis
Left Ventricular Hypertrophy
Chronic Renal Insufficiency
Myocardial Ischemia
Atherosclerosis
Fibrosis
Hemodynamics
Quality of Life
Pharmacology
Inflammation
Technology
Population
Therapeutics

Keywords

  • Cardiovascular complications
  • End stage renal disease
  • Hemodialysis

Cite this

Cardiovascular impact in patients undergoing maintenance hemodialysis : Clinical management considerations. / Chirakarnjanakorn, Srisakul; Navaneethan, Sankar D.; Francis, Gary S.; Tang, W. H Wilson.

In: International Journal of Cardiology, Vol. 232, 01.04.2017, p. 12-23.

Research output: Contribution to journalReview article

Chirakarnjanakorn, Srisakul ; Navaneethan, Sankar D. ; Francis, Gary S. ; Tang, W. H Wilson. / Cardiovascular impact in patients undergoing maintenance hemodialysis : Clinical management considerations. In: International Journal of Cardiology. 2017 ; Vol. 232. pp. 12-23.
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