Improved techniques for intraoperative myocardial preservation have permitted application of cardiac surgery to younger and smaller children with congenital heart disease and to older and sicker adults with coronary and valvular heart disease. Many of these patients experience myocardial failure postoperatively, and require variable periods of positive inotropic drug support. A variety of positive inotropic drugs have shown efficacy in these circumstances, in some cases when administered alone, and in others when administered with other positive inotropes and other vasoactive agents. Conversely, some drugs and drug combinations have proven inferior to others. Careful titration of the appropriate agent, with a full understanding of its potential for adverse side effects and with frequent assessment of the adequacy of drug response, should provide the greatest likelihood of therapeutic success and accelerated recovery.
|Original language||English (US)|
|Number of pages||17|
|Journal||New Horizons: Science and Practice of Acute Medicine|
|State||Published - Dec 1 1999|
- Cardiac surgery
- Heart failure
- Positive inotrope