Cardiovascular disease in Noonan syndrome

Mary Ella Pierpont, Maria Cristina Digilio

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Purpose of review To provide information on the scope of cardiac disease in Noonan syndrome. Recent findings Noonan syndrome is a common autosomal dominant RASopathy disorder characterized by clinical findings of facial dysmorphism, congenital heart disease, and short stature. The degree of genetic heterogeneity has recently become evident in that Noonan syndrome is now known to be caused by mutations in a large variety of genes which produce dysregulation of the RAS-MAPK (mitogen-Activated protein kinase) signaling pathway. The scope of cardiac disease in Noonan syndrome is quite variable depending on the gene mutation, with some mutations usually associated with a high incidence of congenital heart defects (PTPN11, KRAS, and others) while those with predominantly hypertrophic cardiomyopathy (HCM) have higher risk and morbidity profiles (RAF1, RIT1, and those associated with multiple lentigines). Summary Cardiac disease in Noonan syndrome varies according to the type of gene mutation. The most common forms of cardiac disease include pulmonary stenosis, HCM, and atrial septal defect. HCM in general is associated with increased risk, mortality, and morbidity. New concepts for potential treatments are discussed.

Original languageEnglish (US)
Pages (from-to)601-608
Number of pages8
JournalCurrent Opinion in Pediatrics
Volume30
Issue number5
DOIs
StatePublished - Jan 1 2018

Keywords

  • Congenital heart disease
  • Hypertrophic cardiomyopathy
  • Noonan syndrome
  • RASopathy

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