Cardiovascular and neurohormonal effects of atrial natriuretic peptide in conscious dogs with and without chronic left ventricular dysfunction

Peter Carson, Peter Carlyle, Thomas S. Rector, Jay N Cohn

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Atrial natriuretic peptide (hANP 4-28) was infused for 1 h (0.3 μg/kg/min) in 11 normal awake dogs and seven awake dogs with chronic left ventricular dysfunction, induced 16 weeks earlier by repetitive DC shock. The responses were similar in the two groups and included decreases in arterial pressure (107-99 mm Hg), heart rate (83-72 beats/min), and cardiac output (3.6-2.8 L/min), without changes in right or left ventricular filling pressures. Systemic vascular resistance (SVR) tended to rise during the infusion and was significantly increased (2,847-3,442 dyn s cm-5, p < .05) during the postinfusion recovery period. Regional blood flows (microspheres) during infusion revealed a decrease in skin and splanchnic flow. Despite the apparent vasoconstrictor effect, plasma norepinephrine (PNE), renin activity (PRA), and arginine vasopressin (AVP) levels all fell during ANP infusion. These data suggest that ANP exerts a cardioinhibitory effect, possibly similar to that of arginine vasopressin (AVP), and that the net systemic vasoconstrictor effect of ANP in these dogs is mediated by a complex interrelationship between direct vascular effects, neurohormonal inhibition, and central reflex activation.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume16
Issue number2
DOIs
StatePublished - Aug 1990

Fingerprint

Left Ventricular Dysfunction
Atrial Natriuretic Factor
Arginine Vasopressin
Vasoconstrictor Agents
Dogs
Viscera
Regional Blood Flow
Ventricular Pressure
Microspheres
Renin
Cardiac Output
Vascular Resistance
Blood Vessels
Reflex
Shock
Norepinephrine
Arterial Pressure
Heart Rate
Skin
atrial natriuretic factor (4-28)

Keywords

  • Atrial natriuretic peptide
  • Hemodynamics
  • Left ventricular dysfunction
  • Regional blood flow

Cite this

Cardiovascular and neurohormonal effects of atrial natriuretic peptide in conscious dogs with and without chronic left ventricular dysfunction. / Carson, Peter; Carlyle, Peter; Rector, Thomas S.; Cohn, Jay N.

In: Journal of Cardiovascular Pharmacology, Vol. 16, No. 2, 08.1990, p. 305-311.

Research output: Contribution to journalArticle

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