Cardiotoxicity and cardiomyopathy in children and young adult survivors of hematopoietic stem cell transplant

Seth J. Rotz, Thomas D. Ryan, Joel Hlavaty, Stephen A. George, Javier El-Bietar, Christopher E. Dandoy

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Cardiomyopathy is common in long-term survivors of pediatric hematopoietic stem cell transplant (HSCT). Events occurring before and after HSCT when combined with specific insults during HSCT likely contribute to long-term risk. Strategies for detecting subclinical cardiomyopathy prior to patients developing overt heart failure are under investigation. Changes in HSCT preparative regimens and cardioprotective medications administered during chemotherapy may alter the risk for cardiomyopathy. Interventions in long-term survivors such as lifestyle modification and cardioactive medications are of increasing importance. Herein we review the causes of cardiac injury, discuss strategies for detection of cardiomyopathy, and evaluate therapeutic options for long-term HSCT survivors.

Original languageEnglish (US)
Article numbere26600
JournalPediatric Blood and Cancer
Volume64
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • bmt
  • cardiomyopathy
  • cardiotoxicity
  • late effects
  • stem cell transplant
  • survivors

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    Rotz, S. J., Ryan, T. D., Hlavaty, J., George, S. A., El-Bietar, J., & Dandoy, C. E. (2017). Cardiotoxicity and cardiomyopathy in children and young adult survivors of hematopoietic stem cell transplant. Pediatric Blood and Cancer, 64(11), [e26600]. https://doi.org/10.1002/pbc.26600