TY - JOUR
T1 - Cardiorespiratory fitness and brain volume and white matter integrity
T2 - The CARDIA Study
AU - Zhu, Na
AU - Jacobs, David R.
AU - Schreiner, Pamela J.
AU - Launer, Lenore J.
AU - Whitmer, Rachel A.
AU - Sidney, Stephen
AU - Demerath, Ellen
AU - Thomas, William
AU - Bouchard, Claude
AU - He, Ka
AU - Erus, Guray
AU - Battapady, Harsha
AU - Bryan, R. Nick
N1 - Publisher Copyright:
© 2015 American Academy of Neurology.
PY - 2015/6/9
Y1 - 2015/6/9
N2 - Objective: We hypothesized that greater cardiorespiratory fitness is associated with lower odds of having unfavorable brain MRI findings. Methods: We studied 565 healthy, middle-aged, black and white men and women in the CARDIA (Coronary Artery Risk Development in Young Adults) Study. The fitness measure was symptom-limited maximal treadmill test duration (Max dur); brain MRI was measured 5 years later. Brain MRI measures were analyzed as means and as proportions below the 15th percentile (above the 85th percentile for white matter abnormal tissue volume). Results: Per 1-minute-higher Max dur, the odds ratio for having less whole brain volume was 0.85 (p 0.04) and for having low white matter integrity was 0.80 (p 0.02), adjusted for age, race, sex, clinic, body mass index, smoking, alcohol, diet, physical activity, education, blood pressure, diabetes, total cholesterol, and lung function (plus intracranial volume for white matter integrity). No significant associations were observed between Max dur and abnormal tissue volume or blood flow in white matter. Findings were similar for associations with continuous brain MRI measures. Conclusions: Greater physical fitness was associated with more brain volume and greater white matter integrity measured 5 years later in middle-aged adults.
AB - Objective: We hypothesized that greater cardiorespiratory fitness is associated with lower odds of having unfavorable brain MRI findings. Methods: We studied 565 healthy, middle-aged, black and white men and women in the CARDIA (Coronary Artery Risk Development in Young Adults) Study. The fitness measure was symptom-limited maximal treadmill test duration (Max dur); brain MRI was measured 5 years later. Brain MRI measures were analyzed as means and as proportions below the 15th percentile (above the 85th percentile for white matter abnormal tissue volume). Results: Per 1-minute-higher Max dur, the odds ratio for having less whole brain volume was 0.85 (p 0.04) and for having low white matter integrity was 0.80 (p 0.02), adjusted for age, race, sex, clinic, body mass index, smoking, alcohol, diet, physical activity, education, blood pressure, diabetes, total cholesterol, and lung function (plus intracranial volume for white matter integrity). No significant associations were observed between Max dur and abnormal tissue volume or blood flow in white matter. Findings were similar for associations with continuous brain MRI measures. Conclusions: Greater physical fitness was associated with more brain volume and greater white matter integrity measured 5 years later in middle-aged adults.
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U2 - 10.1212/WNL.0000000000001658
DO - 10.1212/WNL.0000000000001658
M3 - Article
C2 - 25957331
AN - SCOPUS:84930742993
VL - 84
SP - 2347
EP - 2353
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 23
ER -