Cardioreparation and the concept of modulating cardiovascular structure and function

Karl T. Weber, Christian G. Brilla, John G.F. Cleland, Jay N. Cohn, Lennart Hansson, Anthony M. Heagerty, John H. Laragh, Stéphane Laurent, Jean Pierre Ollivier, Paolo Pauletto, Hubert Pouleur, Jos F.M. Smits, Lip Bun Tan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Hypertension and atherosclerotic cardiovascular disease represent major global health problems. Practising physicians are challenged daily by patients suffering adverse cardiovascular events, such as myocardial infarction, stroke, heart failure and sudden cardiac death. Major risk factors have been identified of which the most important is left ventricular hypertrophy. In recent years, growth factors, regulatory peptides and effector hormones of the renin-angiotensin-aldosterone system have been identified as important modulators of cell growth and behaviour. It therefore follows that a major emphasis has been placed on the importance of abnormalities in organ structure as the primary basis for impaired function of the heart and vasculature, including large and medium sized arteries and resistance vessels, or arterioles. The concept of reparation recognizes the importance of abnormalities in tissue structure to the functional basis of disease. It suggests that the structurally remodelled heart and vasculature can be restored to, or toward, normal structure and function by suitable therapy. Experimental and clinical trials which address this premise are reviewed herein.

Original languageEnglish (US)
Pages (from-to)6-21
Number of pages16
JournalBlood Pressure
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1993

Fingerprint

Peptide Hormones
Sudden Cardiac Death
Arterioles
Left Ventricular Hypertrophy
Renin-Angiotensin System
Intercellular Signaling Peptides and Proteins
Cardiovascular Diseases
Heart Failure
Arteries
Stroke
Myocardial Infarction
Clinical Trials
Hypertension
Physicians
Growth
Therapeutics
Global Health

Keywords

  • Angiotensin-converting enzyme inhibitors
  • Congestive heart failure
  • Hypertension
  • Left ventricular hypertrophy
  • Left ventricular remodelling
  • Myocardial infarction

Cite this

Weber, K. T., Brilla, C. G., Cleland, J. G. F., Cohn, J. N., Hansson, L., Heagerty, A. M., ... Tan, L. B. (1993). Cardioreparation and the concept of modulating cardiovascular structure and function. Blood Pressure, 2(1), 6-21. https://doi.org/10.3109/08037059309077521

Cardioreparation and the concept of modulating cardiovascular structure and function. / Weber, Karl T.; Brilla, Christian G.; Cleland, John G.F.; Cohn, Jay N.; Hansson, Lennart; Heagerty, Anthony M.; Laragh, John H.; Laurent, Stéphane; Ollivier, Jean Pierre; Pauletto, Paolo; Pouleur, Hubert; Smits, Jos F.M.; Tan, Lip Bun.

In: Blood Pressure, Vol. 2, No. 1, 01.01.1993, p. 6-21.

Research output: Contribution to journalArticle

Weber, KT, Brilla, CG, Cleland, JGF, Cohn, JN, Hansson, L, Heagerty, AM, Laragh, JH, Laurent, S, Ollivier, JP, Pauletto, P, Pouleur, H, Smits, JFM & Tan, LB 1993, 'Cardioreparation and the concept of modulating cardiovascular structure and function', Blood Pressure, vol. 2, no. 1, pp. 6-21. https://doi.org/10.3109/08037059309077521
Weber, Karl T. ; Brilla, Christian G. ; Cleland, John G.F. ; Cohn, Jay N. ; Hansson, Lennart ; Heagerty, Anthony M. ; Laragh, John H. ; Laurent, Stéphane ; Ollivier, Jean Pierre ; Pauletto, Paolo ; Pouleur, Hubert ; Smits, Jos F.M. ; Tan, Lip Bun. / Cardioreparation and the concept of modulating cardiovascular structure and function. In: Blood Pressure. 1993 ; Vol. 2, No. 1. pp. 6-21.
@article{cc9943cb1ea24684bb8a53a7d13e49e7,
title = "Cardioreparation and the concept of modulating cardiovascular structure and function",
abstract = "Hypertension and atherosclerotic cardiovascular disease represent major global health problems. Practising physicians are challenged daily by patients suffering adverse cardiovascular events, such as myocardial infarction, stroke, heart failure and sudden cardiac death. Major risk factors have been identified of which the most important is left ventricular hypertrophy. In recent years, growth factors, regulatory peptides and effector hormones of the renin-angiotensin-aldosterone system have been identified as important modulators of cell growth and behaviour. It therefore follows that a major emphasis has been placed on the importance of abnormalities in organ structure as the primary basis for impaired function of the heart and vasculature, including large and medium sized arteries and resistance vessels, or arterioles. The concept of reparation recognizes the importance of abnormalities in tissue structure to the functional basis of disease. It suggests that the structurally remodelled heart and vasculature can be restored to, or toward, normal structure and function by suitable therapy. Experimental and clinical trials which address this premise are reviewed herein.",
keywords = "Angiotensin-converting enzyme inhibitors, Congestive heart failure, Hypertension, Left ventricular hypertrophy, Left ventricular remodelling, Myocardial infarction",
author = "Weber, {Karl T.} and Brilla, {Christian G.} and Cleland, {John G.F.} and Cohn, {Jay N.} and Lennart Hansson and Heagerty, {Anthony M.} and Laragh, {John H.} and St{\'e}phane Laurent and Ollivier, {Jean Pierre} and Paolo Pauletto and Hubert Pouleur and Smits, {Jos F.M.} and Tan, {Lip Bun}",
year = "1993",
month = "1",
day = "1",
doi = "10.3109/08037059309077521",
language = "English (US)",
volume = "2",
pages = "6--21",
journal = "Blood Pressure",
issn = "0803-7051",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Cardioreparation and the concept of modulating cardiovascular structure and function

AU - Weber, Karl T.

AU - Brilla, Christian G.

AU - Cleland, John G.F.

AU - Cohn, Jay N.

AU - Hansson, Lennart

AU - Heagerty, Anthony M.

AU - Laragh, John H.

AU - Laurent, Stéphane

AU - Ollivier, Jean Pierre

AU - Pauletto, Paolo

AU - Pouleur, Hubert

AU - Smits, Jos F.M.

AU - Tan, Lip Bun

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Hypertension and atherosclerotic cardiovascular disease represent major global health problems. Practising physicians are challenged daily by patients suffering adverse cardiovascular events, such as myocardial infarction, stroke, heart failure and sudden cardiac death. Major risk factors have been identified of which the most important is left ventricular hypertrophy. In recent years, growth factors, regulatory peptides and effector hormones of the renin-angiotensin-aldosterone system have been identified as important modulators of cell growth and behaviour. It therefore follows that a major emphasis has been placed on the importance of abnormalities in organ structure as the primary basis for impaired function of the heart and vasculature, including large and medium sized arteries and resistance vessels, or arterioles. The concept of reparation recognizes the importance of abnormalities in tissue structure to the functional basis of disease. It suggests that the structurally remodelled heart and vasculature can be restored to, or toward, normal structure and function by suitable therapy. Experimental and clinical trials which address this premise are reviewed herein.

AB - Hypertension and atherosclerotic cardiovascular disease represent major global health problems. Practising physicians are challenged daily by patients suffering adverse cardiovascular events, such as myocardial infarction, stroke, heart failure and sudden cardiac death. Major risk factors have been identified of which the most important is left ventricular hypertrophy. In recent years, growth factors, regulatory peptides and effector hormones of the renin-angiotensin-aldosterone system have been identified as important modulators of cell growth and behaviour. It therefore follows that a major emphasis has been placed on the importance of abnormalities in organ structure as the primary basis for impaired function of the heart and vasculature, including large and medium sized arteries and resistance vessels, or arterioles. The concept of reparation recognizes the importance of abnormalities in tissue structure to the functional basis of disease. It suggests that the structurally remodelled heart and vasculature can be restored to, or toward, normal structure and function by suitable therapy. Experimental and clinical trials which address this premise are reviewed herein.

KW - Angiotensin-converting enzyme inhibitors

KW - Congestive heart failure

KW - Hypertension

KW - Left ventricular hypertrophy

KW - Left ventricular remodelling

KW - Myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=0027193579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027193579&partnerID=8YFLogxK

U2 - 10.3109/08037059309077521

DO - 10.3109/08037059309077521

M3 - Article

C2 - 8193734

AN - SCOPUS:0027193579

VL - 2

SP - 6

EP - 21

JO - Blood Pressure

JF - Blood Pressure

SN - 0803-7051

IS - 1

ER -