Cardioreparation and the concept of modulating cardiovascular structure and function

Karl T. Weber, Christian G. Brilla, John G.F. Cleland, Jay N. Cohn, Lennart Hansson, Anthony M. Heagerty, John H. Laragh, Stéphane Laurent, Jean Pierre Ollivier, Paolo Pauletto, Hubert Pouleur, Jos F.M. Smits, Lip Bun Tan

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Hypertension and atherosclerotic cardiovascular disease represent major global health problems. Practising physicians are challenged daily by patients suffering adverse cardiovascular events, such as myocardial infarction, stroke, heart failure and sudden cardiac death. Major risk factors have been identified of which the most important is left ventricular hypertrophy. In recent years, growth factors, regulatory peptides and effector hormones of the renin-angiotensin-aldosterone system have been identified as important modulators of cell growth and behaviour. It therefore follows that a major emphasis has been placed on the importance of abnormalities in organ structure as the primary basis for impaired function of the heart and vasculature, including large and medium sized arteries and resistance vessels, or arterioles. The concept of reparation recognizes the importance of abnormalities in tissue structure to the functional basis of disease. It suggests that the structurally remodelled heart and vasculature can be restored to, or toward, normal structure and function by suitable therapy. Experimental and clinical trials which address this premise are reviewed herein.

Original languageEnglish (US)
Pages (from-to)6-21
Number of pages16
JournalBlood Pressure
Volume2
Issue number1
DOIs
StatePublished - 1993

Bibliographical note

Funding Information:
The meeting from which this review was derived was made possible by an educational grant from ICI Pharmaceuticals. We acknowledge Adelphi Communications for their editorial services and the following for their contributions to the symposium: Edward Barin, Javier Diez, Concepcion Laviades, Lorenza Muiesan, Michel Pathe, Ole Lederballe Pedersen, Jorg Slany, Otto A. Smiseth, Giuseppe Specchia, Ulf Thilen, Jean Varin, Wolfgang Waas.

Keywords

  • Angiotensin-converting enzyme inhibitors
  • Congestive heart failure
  • Hypertension
  • Left ventricular hypertrophy
  • Left ventricular remodelling
  • Myocardial infarction

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