TY - JOUR
T1 - Cardiorenal syndrome
T2 - A cardiologist's perspective of pathophysiology
AU - Anand, Inder
PY - 2013/10/7
Y1 - 2013/10/7
N2 - The cardiorenal syndrome has recently been defined as "disorders of the heart and kidney whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other." The syndrome is extremely common and independently associated with poor clinical outcomes. However, no pharmacological therapy has been shown to improve its outcomes. Unfortunately, the mechanisms that initiate the development of renal dysfunction in heart failure are still debated. This review tries to clarify some of the misunderstanding regarding the principle hemodynamic factors that drive the kidneys to retain salt and water.
AB - The cardiorenal syndrome has recently been defined as "disorders of the heart and kidney whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other." The syndrome is extremely common and independently associated with poor clinical outcomes. However, no pharmacological therapy has been shown to improve its outcomes. Unfortunately, the mechanisms that initiate the development of renal dysfunction in heart failure are still debated. This review tries to clarify some of the misunderstanding regarding the principle hemodynamic factors that drive the kidneys to retain salt and water.
UR - http://www.scopus.com/inward/record.url?scp=84885236737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885236737&partnerID=8YFLogxK
U2 - 10.2215/CJN.04090413
DO - 10.2215/CJN.04090413
M3 - Article
C2 - 23886565
AN - SCOPUS:84885236737
SN - 1555-9041
VL - 8
SP - 1800
EP - 1807
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 10
ER -