Cardiopoietic index predicts heart repair fitness of patient-derived stem cells

Ruben J Crespo-Diaz, Satsuki Yamada, Jozef Bartunek, Carmen Perez-Terzic, Peter De Waele, Sébastien Mauën, Andre Terzic, Atta Behfar

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. Aim: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. Materials & methods: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. Results: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. Conclusion: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.

Original languageEnglish (US)
Pages (from-to)639-649
Number of pages11
JournalBiomarkers in Medicine
Volume9
Issue number7
DOIs
StatePublished - Jul 2015

Keywords

  • cardiopoiesis
  • cardiopoietic stem cells
  • heart failure
  • mesenchymal
  • regenerative medicine
  • stem cells

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