Cardiomyopathy-associated variants alter the structure and function of the α-actinin-2 actin-binding domain

Keyphrases

• Cardiomyopathy 100%
• Actin Binding Domain 100%
• Actinin 100%
• Actin Binding 80%
• Hypertrophic Cardiomyopathy 60%
• Dilated Cardiomyopathy 40%
• Restrictive Cardiomyopathy 40%
• Cardiomyopathy Dilated 40%
• ACTN2 40%
• Heart Failure 20%
• Pathogenicity 20%
• Substructure 20%
• Diastolic Dysfunction 20%
• Cardiomyopathy mutations 20%
• Sudden Cardiac Death 20%
• Circular Dichroism 20%
• Ventricular Myocardium 20%
• Functional Data 20%
• Systolic Dysfunction 20%
• Missense Variants 20%
• Thermal Denaturation 20%
• Denaturation Studies 20%
• Folded State 20%
• ClinVar 20%
• Structural Disruption 20%
• Molecular Consequences 20%

Biochemistry, Genetics and Molecular Biology

• Binding Domain 100%
• Actinin 100%
• Actin 100%
• Missense 11%
• Denaturation 11%
• Sudden Cardiac Death 11%
• Circular Dichroism 11%