Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)

Amy K. Saenger; Allan S. Jaffe; Richard Body; Paul O. Collinson; Peter A. Kavsak; Carolyn S.P. Lam; Guillaume Lefèvre; Tobjørn Omland; Jordi Ordóñez-Llanos; Kari Pulkki; Fred S. Apple

doi:10.1515/cclm-2018-0905

Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)

Amy K. Saenger, Allan S. Jaffe, Richard Body, Paul O. Collinson, Peter A. Kavsak, Carolyn S.P. Lam, Guillaume Lefèvre, Tobjørn Omland, Jordi Ordóñez-Llanos, Kari Pulkki, Fred S. Apple

Laboratory Medicine and Pathology

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30 Scopus citations

Abstract

Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker analytical results that are discordant with the clinical situation.

Original language	English (US)
Pages (from-to)	633-640
Number of pages	8
Journal	Clinical Chemistry and Laboratory Medicine
Volume	57
Issue number	5
DOIs	https://doi.org/10.1515/cclm-2018-0905
State	Published - Apr 1 2019

Bibliographical note

Publisher Copyright:
© 2019 Walter de Gruyter GmbH, Berlin/Boston 2019.

Keywords

biotin
hemolysis
interferences
natriuretic peptide
troponin

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10.1515/cclm-2018-0905

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Saenger, A. K., Jaffe, A. S., Body, R., Collinson, P. O., Kavsak, P. A., Lam, C. S. P., Lefèvre, G., Omland, T., Ordóñez-Llanos, J., Pulkki, K., & Apple, F. S. (2019). Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB). Clinical Chemistry and Laboratory Medicine, 57(5), 633-640. https://doi.org/10.1515/cclm-2018-0905

Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB). / Saenger, Amy K.; Jaffe, Allan S.; Body, Richard et al.
In: Clinical Chemistry and Laboratory Medicine, Vol. 57, No. 5, 01.04.2019, p. 633-640.

Research output: Contribution to journal › Article › peer-review

Saenger, AK, Jaffe, AS, Body, R, Collinson, PO, Kavsak, PA, Lam, CSP, Lefèvre, G, Omland, T, Ordóñez-Llanos, J, Pulkki, K & Apple, FS 2019, 'Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)', Clinical Chemistry and Laboratory Medicine, vol. 57, no. 5, pp. 633-640. https://doi.org/10.1515/cclm-2018-0905

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abstract = "Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker analytical results that are discordant with the clinical situation.",

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Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)

Abstract

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