Cardiac transplantation: Immunobiology and immunotherapy

Ziad Taimeh, Daniel J. Garry

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The first successful heart transplant in 1967 brought hope for those with end-stage heart disease. Unfortunately, survival posttransplant was limited in the early years, mainly due to acute rejection and complications from immunosuppressive therapy. Over the decades, advances in tissue typing and donor-recipient matching, as well as in immunotherapy gradually increased the numbers of patients receiving heart transplants and their survival rates. This chapter details the immune system and its critical role in transplant success. It also describes how various immunosuppressive agents can overcome challenges posed by the immune system and lead to enhanced acceptance/tolerance of the donor heart.

Original languageEnglish (US)
Title of host publicationCongestive Heart Failure and Cardiac Transplantation
Subtitle of host publicationClinical, Pathology, Imaging and Molecular Profiles
PublisherSpringer International Publishing
Pages449-467
Number of pages19
ISBN (Electronic)9783319445779
ISBN (Print)9783319445755
DOIs
StatePublished - Jun 1 2017

Keywords

  • Adaptive immunity
  • Cardiac transplantation
  • Complement cascade
  • Cyclosporine
  • Immunosuppressive agents
  • Immunosuppressive therapy
  • Transplant immunobiology

Fingerprint Dive into the research topics of 'Cardiac transplantation: Immunobiology and immunotherapy'. Together they form a unique fingerprint.

  • Cite this

    Taimeh, Z., & Garry, D. J. (2017). Cardiac transplantation: Immunobiology and immunotherapy. In Congestive Heart Failure and Cardiac Transplantation: Clinical, Pathology, Imaging and Molecular Profiles (pp. 449-467). Springer International Publishing. https://doi.org/10.1007/978-3-319-44577-9_27