Cardiac tissue engineering for the treatment of heart failure post-infarction

Jacqueline S. Wendel, Robert T. Tranquillo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell-based therapy has become an attractive solution to the high incidence of heart failure post-infarction. Many current approaches to cell delivery post-infarction result in poor cell engraftment resulting in limited functional benefits. Thus, the use of engineered tissues to deliver cells to the injured myocardium or replace myocardium post infarction has been a topic of increasing interest. Tissue engineering provides a platform for the delivery of a large number of cells to the injured myocardium with high retention, allowing for in vitro development of cellular organization, intracellular communication and ECM deposition. This chapter will discuss the currently used methods to create engineered cardiac tissues, including scaffolds, cells, and cellular conditioning. This chapter will also review the efficacy of these patches in limiting left ventricular remodeling post-infarction in vivo.

Original languageEnglish (US)
Title of host publicationCardiac Fibrosis and Heart Failure
Subtitle of host publicationCause or Effect?
PublisherSpringer International Publishing
Pages405-418
Number of pages14
ISBN (Electronic)9783319174372
ISBN (Print)9783319174365
DOIs
StatePublished - Jan 1 2015

Keywords

  • Biomaterials
  • Bioreactor conditioning
  • Cyclic stretch
  • Electrical stimulation
  • Embryonic stem cells
  • Endothelial cells
  • Induced pluripotent stem cells
  • Myocardial infarction
  • Perfusion
  • Tissue engineering

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