Cardiac tissue engineering: A pathway for repair

Rebecca Hortensius; Wei-Han Lin; Jake F. Fontenot; Brenda M. Ogle; Philip Jung

doi:10.1007/978-3-031-71067-4_15

Cardiac tissue engineering: A pathway for repair

Rebecca Hortensius
, Wei-Han Lin
, Jake F. Fontenot
, Brenda M. Ogle
, Philip Jung

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cardiovascular disease is the leading cause of death globally, accounting for 31.5% of deaths worldwide. The widespread (and growing) prevalence of cardiovascular disease and the inadequacy of the adult human heart to regenerate on its own after a major ischemic event calls for the development of tissue regeneration strategies to facilitate and support cardiomyocyte maturation and function in vivo. This chapter explores regenerative therapies of graded levels of complexity with cell transplantation, engineered biomaterials for cardiac differentiation/ maturation, and functional grafts with perfusable vasculature. Further, a few representative engineering models of cardiac fibrosis are discussed, which achieve a degree of functional improvement of the heart after myocardial infarction.

Original language	English (US)
Title of host publication	Cardiac Electrophysiology Methods and Models
Subtitle of host publication	A Practical Handbook for Scientists, Engineers, and Clinicians
Publisher	Springer Nature
Pages	433-472
Number of pages	40
ISBN (Electronic)	9783031710674
ISBN (Print)	9783031710667
DOIs	https://doi.org/10.1007/978-3-031-71067-4_15
State	Published - Dec 24 2024

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2010, 2024. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3D bioprinting
Cardiac fibrosis
Cardiac muscle repair
Cardiac tissue bioengineering
Cardiac tissue regeneration
Cardiomyocyte transplantation
Stem cell therapy

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10.1007/978-3-031-71067-4_15

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AU - Fontenot, Jake F.

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PY - 2024/12/24

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KW - Cardiac tissue bioengineering

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ER -

Cardiac tissue engineering: A pathway for repair

Abstract

Bibliographical note

UN SDGs

Keywords

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