Cardiac tissue engineering: A pathway for repair

Rebecca Hortensius, Wei Han Lin, Brenda M. Ogle

Research output: Chapter in Book/Report/Conference proceedingChapter


Cardiovascular disease (CVD) is the leading cause of death globally, accounting for 31.5% of deaths worldwide. The widespread (and growing) prevalence of CVD and the inadequacy of the adult human heart to regenerate on its own after a major ischemic event calls for the development of tissue regeneration strategies to facilitate and support cardiomyocyte maturation and function in vivo. This chapter explores regenerative therapies of graded levels of complexity beginning with cell transplantation and ending with a full thickness graft with perfusable vasculature.

Original languageEnglish (US)
Title of host publicationEngineering in Medicine
Subtitle of host publicationAdvances and Challenges
Number of pages31
ISBN (Electronic)9780128130681
ISBN (Print)9780128135143
StatePublished - Jan 1 2018


  • 3D bioprinting
  • Cardiac muscle repair
  • Cardiac tissue bioengineering
  • Cardiac tissue regeneration
  • Cardiomyocyte transplantation
  • Stem cell therapy

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  • Cite this

    Hortensius, R., Lin, W. H., & Ogle, B. M. (2018). Cardiac tissue engineering: A pathway for repair. In Engineering in Medicine: Advances and Challenges (pp. 3-33). Elsevier.