Cardiac sympathetic denervation preceding motor signs in Parkinson disease*

David S. Goldstein, Yehonatan Sharabi, Barbara I. Karp, Oladi Bentho, Ahmed Saleem, Karel Pacak, Graeme Eisenhofer

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.

Original languageEnglish (US)
Pages (from-to)S47-S50
JournalCleveland Clinic journal of medicine
Volume76
Issue numberSUPPL.2
DOIs
StatePublished - 2009

Fingerprint Dive into the research topics of 'Cardiac sympathetic denervation preceding motor signs in Parkinson disease<sup>*</sup>'. Together they form a unique fingerprint.

  • Cite this

    Goldstein, D. S., Sharabi, Y., Karp, B. I., Bentho, O., Saleem, A., Pacak, K., & Eisenhofer, G. (2009). Cardiac sympathetic denervation preceding motor signs in Parkinson disease*. Cleveland Clinic journal of medicine, 76(SUPPL.2), S47-S50. https://doi.org/10.3949/ccjm.76.s2.10