Cardiac Sarcomere Signaling in Health and Disease

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point upon which cardiac muscle contraction occurs. This review focuses on the many signaling components and mechanisms of regulation that impact cardiac sarcomere function. We highlight the roles of the thick and thin filament, both as necessary structural and regulatory building blocks of the sarcomere as well as targets of functionally impactful modifications. Currently, a new focus emerging in the field is inter-myofilament signaling, and we discuss here the important mediators of this mechanism, including myosin-binding protein C and titin. As the understanding of sarcomere signaling advances, so do the methods with which it is studied. This is reviewed here through discussion of recent live muscle systems in which the sarcomere can be studied under intact, physiologically relevant conditions.

Original languageEnglish (US)
Article number16223
JournalInternational journal of molecular sciences
Volume23
Issue number24
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
This work was funded by the NIH grant number R01AR071349, R01HL138490, R01AR079477, R01HL122323, and R01HL132874, the AHA grant number 834921, the Muscular Dystrophy Association grant number 869335, and the Regenerative Medicine Minnesota grant.

Publisher Copyright:
© 2022 by the authors.

Keywords

  • cardiac muscle
  • heart disease
  • myosin
  • myosin-binding protein c
  • sarcomere
  • titin
  • troponin

PubMed: MeSH publication types

  • Journal Article
  • Review

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