Cardiac Resynchronization and Circulating Markers of Sarcoplasmic Reticulum Calcium Handling and Sudden Death Risk

Ning Jiang; Anyu Zhou; Hafiz Imran; Guangbin Shi; Bahaa Kaseer; Vincent Siu; Antony F. Chu; David M. Donaldson; Malcolm M. Kirk; Binu B. Philips; Samuel C. Dudley

doi:10.1016/j.jacep.2021.07.003

Cardiac Resynchronization and Circulating Markers of Sarcoplasmic Reticulum Calcium Handling and Sudden Death Risk

Ning Jiang, Anyu Zhou, Hafiz Imran, Guangbin Shi, Bahaa Kaseer, Vincent Siu, Antony F. Chu, David M. Donaldson, Malcolm M. Kirk, Binu B. Philips, Samuel C. Dudley

Medicine - Cardiology Division

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Cardiac resynchronization therapy (CRT) can improve heart function and decrease arrhythmic events. We tested whether CRT altered circulating markers of calcium handling and sudden death risk. Circulating cardiac sodium channel messenger RNA (mRNA) splicing variants indicate arrhythmic risk, and a reduction in sarco/endoplasmic reticulum calcium adenosine triphosphatase 2a (SERCA2a) is thought to diminish contractility in heart failure. CRT was associated with a decreased proportion of circulating, nonfunctional sodium channels and improved SERCA2a mRNA expression. Patients without CRT did not have improvement in the biomarkers. These changes might explain the lower arrhythmic risk and improved contractility associated with CRT.

Original language	English (US)
Pages (from-to)	1079-1083
Number of pages	5
Journal	JACC: Clinical Electrophysiology
Volume	7
Issue number	9
DOIs	https://doi.org/10.1016/j.jacep.2021.07.003
State	Published - Sep 2021

Bibliographical note

Funding Information:
Dr Dudley is the inventor on the following patent applications: SCN5A Splice Variants for Use in Methods Relating to Sudden Cardiac Death and Need for Implanted Cardiac Defibrillators, PCT/US2012/20564; and SCN5A Splicing Factors and Splice Variants for Use in Diagnostic and Prognostic Methods, 13/291,826. Supported by National Institutes of Health grants R01 HL104025 and HL106592. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publisher Copyright:
© 2021 American College of Cardiology Foundation

Keywords

biomarker
calcium
implantable cardioverter-defibrillator
ion channels
sodium channel

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacep.2021.07.003

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abstract = "Cardiac resynchronization therapy (CRT) can improve heart function and decrease arrhythmic events. We tested whether CRT altered circulating markers of calcium handling and sudden death risk. Circulating cardiac sodium channel messenger RNA (mRNA) splicing variants indicate arrhythmic risk, and a reduction in sarco/endoplasmic reticulum calcium adenosine triphosphatase 2a (SERCA2a) is thought to diminish contractility in heart failure. CRT was associated with a decreased proportion of circulating, nonfunctional sodium channels and improved SERCA2a mRNA expression. Patients without CRT did not have improvement in the biomarkers. These changes might explain the lower arrhythmic risk and improved contractility associated with CRT.",

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author = "Ning Jiang and Anyu Zhou and Hafiz Imran and Guangbin Shi and Bahaa Kaseer and Vincent Siu and Chu, {Antony F.} and Donaldson, {David M.} and Kirk, {Malcolm M.} and Philips, {Binu B.} and Dudley, {Samuel C.}",

note = "Funding Information: Dr Dudley is the inventor on the following patent applications: SCN5A Splice Variants for Use in Methods Relating to Sudden Cardiac Death and Need for Implanted Cardiac Defibrillators, PCT/US2012/20564; and SCN5A Splicing Factors and Splice Variants for Use in Diagnostic and Prognostic Methods, 13/291,826. Supported by National Institutes of Health grants R01 HL104025 and HL106592. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2021 American College of Cardiology Foundation",

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doi = "10.1016/j.jacep.2021.07.003",

language = "English (US)",

volume = "7",

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AU - Jiang, Ning

AU - Zhou, Anyu

AU - Imran, Hafiz

AU - Shi, Guangbin

AU - Kaseer, Bahaa

AU - Siu, Vincent

AU - Chu, Antony F.

AU - Donaldson, David M.

AU - Kirk, Malcolm M.

AU - Philips, Binu B.

AU - Dudley, Samuel C.

N1 - Funding Information: Dr Dudley is the inventor on the following patent applications: SCN5A Splice Variants for Use in Methods Relating to Sudden Cardiac Death and Need for Implanted Cardiac Defibrillators, PCT/US2012/20564; and SCN5A Splicing Factors and Splice Variants for Use in Diagnostic and Prognostic Methods, 13/291,826. Supported by National Institutes of Health grants R01 HL104025 and HL106592. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: © 2021 American College of Cardiology Foundation

PY - 2021/9

Y1 - 2021/9

N2 - Cardiac resynchronization therapy (CRT) can improve heart function and decrease arrhythmic events. We tested whether CRT altered circulating markers of calcium handling and sudden death risk. Circulating cardiac sodium channel messenger RNA (mRNA) splicing variants indicate arrhythmic risk, and a reduction in sarco/endoplasmic reticulum calcium adenosine triphosphatase 2a (SERCA2a) is thought to diminish contractility in heart failure. CRT was associated with a decreased proportion of circulating, nonfunctional sodium channels and improved SERCA2a mRNA expression. Patients without CRT did not have improvement in the biomarkers. These changes might explain the lower arrhythmic risk and improved contractility associated with CRT.

AB - Cardiac resynchronization therapy (CRT) can improve heart function and decrease arrhythmic events. We tested whether CRT altered circulating markers of calcium handling and sudden death risk. Circulating cardiac sodium channel messenger RNA (mRNA) splicing variants indicate arrhythmic risk, and a reduction in sarco/endoplasmic reticulum calcium adenosine triphosphatase 2a (SERCA2a) is thought to diminish contractility in heart failure. CRT was associated with a decreased proportion of circulating, nonfunctional sodium channels and improved SERCA2a mRNA expression. Patients without CRT did not have improvement in the biomarkers. These changes might explain the lower arrhythmic risk and improved contractility associated with CRT.

KW - biomarker

KW - calcium

KW - implantable cardioverter-defibrillator

KW - ion channels

KW - sodium channel

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Cardiac Resynchronization and Circulating Markers of Sarcoplasmic Reticulum Calcium Handling and Sudden Death Risk

Abstract

Bibliographical note

Keywords

UN SDGs

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