Cardiac phase-resolved late gadolinium enhancement imaging

Sebastian Weingärtner, Ömer B. Demirel, Francisco Gama, Iain Pierce, Thomas A. Treibel, Jeanette Schulz-Menger, Mehmet Akçakaya

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) imaging is the clinical reference for assessment of myocardial scar and focal fibrosis. However, current LGE techniques are confined to imaging of a single cardiac phase, which hampers assessment of scar motility and does not allow cross-comparison between multiple phases. In this work, we investigate a three step approach to obtain cardiac phase-resolved LGE images: (1) Acquisition of cardiac phase-resolved imaging data with varying T 1 weighting. (2) Generation of semi-quantitative T 1 * maps for each cardiac phase. (3) Synthetization of LGE contrast to obtain functional LGE images. The proposed method is evaluated in phantom imaging, six healthy subjects at 3T and 20 patients at 1.5T. Phantom imaging at 3T demonstrates consistent contrast throughout the cardiac cycle with a coefficient of variation of 2.55 ± 0.42%. In-vivo results show reliable LGE contrast with thorough suppression of the myocardial tissue is healthy subjects. The contrast between blood and myocardium showed moderate variation throughout the cardiac cycle in healthy subjects (coefficient of variation 18.2 ± 3.51%). Images were acquired at 40-60 ms and 80 ms temporal resolution, at 3T and 1.5, respectively. Functional LGE images acquired in patients with myocardial scar visualized scar tissue throughout the cardiac cycle, albeit at noticeably lower imaging resolution and noise resilience than the reference technique. The proposed technique bears the promise of integrating the advantages of phase-resolved CMR with LGE imaging, but further improvements in the acquisition quality are warranted for clinical use.

Original languageEnglish (US)
Article number917180
JournalFrontiers in Cardiovascular Medicine
StatePublished - Sep 29 2022

Bibliographical note

Funding Information:
The authors thank Bianca Linssen, Rick Voncken, and SCANNEXUS for their resources and support with the phantom experiment.

Funding Information:
This work was supported in part by the 4TU federation, a NWO Start-up grant STU.019.024, ZonMW Off-Road 04510011910073, NIH R01HL153146, NIH R21EB028369, NIH P41EB027061, and NSF CAREER CCF-1651825. ÖD was partially supported by an AHA Predoctoral Fellowship. TT was funded by a BHF Intermediate Research Fellowship (FS/19/35/34374) and directly and indirectly supported by the UCLH NIHR Biomedical Research Centre and Biomedical Research Unit at UCLH and Barts, respectively.

Publisher Copyright:
Copyright © 2022 Weingärtner, Demirel, Gama, Pierce, Treibel, Schulz-Menger and Akçakaya.


  • LGE imaging
  • MRI sequence development
  • T1 mapping
  • cardiac magnetic resonance (CMR)
  • magnetic resonance imaging
  • myocardial tissue characterization

Center for Magnetic Resonance Research (CMRR) tags

  • BI
  • NMC
  • IRP

PubMed: MeSH publication types

  • Journal Article


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