Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Research output: Contribution to journalReview article

Abstract

The phospholipid bilayer membrane that surrounds each cell in the body represents the first and last line of defense for preserving overall cell viability. In several forms of cardiac and skeletal muscle disease, deficits in the integrity of the muscle membrane play a central role in disease pathogenesis. In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is the primary cause of disease, including significant heart disease, for which there is no cure or highly effective treatment. Further, in multiple clinical forms of myocardial ischemia-reperfusion injury, the cardiac sarcolemma is damaged and this plays a key role in disease etiology. In this review, cardiac muscle membrane stability is addressed, with a focus on synthetic block copolymers as a unique chemical-based approach to stabilize damaged muscle membranes. Recent advances using clinically relevant small and large animal models of heart disease are discussed. In addition, mechanistic insights into the copolymer-muscle membrane interface, featuring atomistic, molecular, and physiological structure-function approaches are highlighted. Collectively, muscle membrane instability contributes significantly to morbidity and mortality in prominent acquired and inherited heart diseases. In this context, chemical-based muscle membrane stabilizers provide a novel therapeutic approach for a myriad of heart diseases wherein the integrity of the cardiac muscle membrane is at risk.

Original languageEnglish (US)
Pages (from-to)275-287
Number of pages13
JournalJACC: Basic to Translational Science
Volume4
Issue number2
DOIs
StatePublished - Apr 1 2019

Fingerprint

Myocardial Reperfusion Injury
Myocardium
Membranes
Muscles
Heart Diseases
Sarcolemma
Duchenne Muscular Dystrophy
Molecular Structure
Reperfusion Injury
Myocardial Ischemia
Phospholipids
Cell Survival
Skeletal Muscle
Animal Models
Morbidity

Keywords

  • copolymer
  • heart
  • ischemia
  • reperfusion

PubMed: MeSH publication types

  • Journal Article
  • Review

Cite this

@article{5d1722fc49734a9cb5cfb1913f64c322,
title = "Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury",
abstract = "The phospholipid bilayer membrane that surrounds each cell in the body represents the first and last line of defense for preserving overall cell viability. In several forms of cardiac and skeletal muscle disease, deficits in the integrity of the muscle membrane play a central role in disease pathogenesis. In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is the primary cause of disease, including significant heart disease, for which there is no cure or highly effective treatment. Further, in multiple clinical forms of myocardial ischemia-reperfusion injury, the cardiac sarcolemma is damaged and this plays a key role in disease etiology. In this review, cardiac muscle membrane stability is addressed, with a focus on synthetic block copolymers as a unique chemical-based approach to stabilize damaged muscle membranes. Recent advances using clinically relevant small and large animal models of heart disease are discussed. In addition, mechanistic insights into the copolymer-muscle membrane interface, featuring atomistic, molecular, and physiological structure-function approaches are highlighted. Collectively, muscle membrane instability contributes significantly to morbidity and mortality in prominent acquired and inherited heart diseases. In this context, chemical-based muscle membrane stabilizers provide a novel therapeutic approach for a myriad of heart diseases wherein the integrity of the cardiac muscle membrane is at risk.",
keywords = "copolymer, heart, ischemia, reperfusion",
author = "Houang, {Evelyne M.} and Bartos, {Jason A} and Hackel, {Benjamin J} and Lodge, {Timothy P} and Demetri Yannopoulos and Bates, {Frank S} and Metzger, {Joseph M}",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.jacbts.2019.01.009",
language = "English (US)",
volume = "4",
pages = "275--287",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

AU - Houang, Evelyne M.

AU - Bartos, Jason A

AU - Hackel, Benjamin J

AU - Lodge, Timothy P

AU - Yannopoulos, Demetri

AU - Bates, Frank S

AU - Metzger, Joseph M

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The phospholipid bilayer membrane that surrounds each cell in the body represents the first and last line of defense for preserving overall cell viability. In several forms of cardiac and skeletal muscle disease, deficits in the integrity of the muscle membrane play a central role in disease pathogenesis. In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is the primary cause of disease, including significant heart disease, for which there is no cure or highly effective treatment. Further, in multiple clinical forms of myocardial ischemia-reperfusion injury, the cardiac sarcolemma is damaged and this plays a key role in disease etiology. In this review, cardiac muscle membrane stability is addressed, with a focus on synthetic block copolymers as a unique chemical-based approach to stabilize damaged muscle membranes. Recent advances using clinically relevant small and large animal models of heart disease are discussed. In addition, mechanistic insights into the copolymer-muscle membrane interface, featuring atomistic, molecular, and physiological structure-function approaches are highlighted. Collectively, muscle membrane instability contributes significantly to morbidity and mortality in prominent acquired and inherited heart diseases. In this context, chemical-based muscle membrane stabilizers provide a novel therapeutic approach for a myriad of heart diseases wherein the integrity of the cardiac muscle membrane is at risk.

AB - The phospholipid bilayer membrane that surrounds each cell in the body represents the first and last line of defense for preserving overall cell viability. In several forms of cardiac and skeletal muscle disease, deficits in the integrity of the muscle membrane play a central role in disease pathogenesis. In Duchenne muscular dystrophy, an inherited and uniformly fatal disease of progressive muscle deterioration, muscle membrane instability is the primary cause of disease, including significant heart disease, for which there is no cure or highly effective treatment. Further, in multiple clinical forms of myocardial ischemia-reperfusion injury, the cardiac sarcolemma is damaged and this plays a key role in disease etiology. In this review, cardiac muscle membrane stability is addressed, with a focus on synthetic block copolymers as a unique chemical-based approach to stabilize damaged muscle membranes. Recent advances using clinically relevant small and large animal models of heart disease are discussed. In addition, mechanistic insights into the copolymer-muscle membrane interface, featuring atomistic, molecular, and physiological structure-function approaches are highlighted. Collectively, muscle membrane instability contributes significantly to morbidity and mortality in prominent acquired and inherited heart diseases. In this context, chemical-based muscle membrane stabilizers provide a novel therapeutic approach for a myriad of heart diseases wherein the integrity of the cardiac muscle membrane is at risk.

KW - copolymer

KW - heart

KW - ischemia

KW - reperfusion

UR - http://www.scopus.com/inward/record.url?scp=85064453923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064453923&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2019.01.009

DO - 10.1016/j.jacbts.2019.01.009

M3 - Review article

C2 - 31061929

AN - SCOPUS:85064453923

VL - 4

SP - 275

EP - 287

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

SN - 2452-302X

IS - 2

ER -