Cardiac Embryology and Molecular Mechanisms of Congenital Heart Disease: A Primer for Anesthesiologists

Benjamin Kloesel, James A. Dinardo, Simon C. Body

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Congenital heart disease is diagnosed in 0.4% to 5% of live births and presents unique challenges to the pediatric anesthesiologist. Furthermore, advances in surgical management have led to improved survival of those patients, and many adult anesthesiologists now frequently take care of adolescents and adults who have previously undergone surgery to correct or palliate congenital heart lesions. Knowledge of abnormal heart development on the molecular and genetic level extends and improves the anesthesiologist's understanding of congenital heart disease. In this article, we aim to review current knowledge pertaining to genetic alterations and their cellular effects that are involved in the formation of congenital heart defects. Given that congenital heart disease can currently only occasionally be traced to a single genetic mutation, we highlight some of the difficulties that researchers face when trying to identify specific steps in the pathogenetic development of heart lesions.

Original languageEnglish (US)
Pages (from-to)551-569
Number of pages19
JournalAnesthesia and analgesia
Volume123
Issue number3
DOIs
StatePublished - Sep 1 2016

Bibliographical note

Funding Information:
This work was supported by funding from the National Institutes of Health (R01HL114823) to SCB

Publisher Copyright:
Copyright © 2016 International Anesthesia Research Society.

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