Cardiac action potentials, ion channels, and gap junctions

Daniel C. Sigg; Tina Batista Napotnik; Paul A. Iaizzo

doi:10.1007/978-3-031-71067-4_3

Cardiac action potentials, ion channels, and gap junctions

Daniel C. Sigg
, Tina Batista Napotnik
, Paul A. Iaizzo

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

It is the interplay between various ion channels within the membranes of cardiomyocytes that is responsible for depolarization and repolarization of the heart cells. Cell-to-cell coupling between myocytes is mediated via gap junction proteins and is involved in overall propagation of action potentials throughout the heart. In this chapter, different phases of the action potential of heart cells are discussed, and the role and characteristics of the most important ion channels that are active during these phases are conferred. Differences in the expressions of the various ion and gap junction channels under normal and certain pathological conditions are described.

Original language	English (US)
Title of host publication	Cardiac Electrophysiology Methods and Models
Subtitle of host publication	A Practical Handbook for Scientists, Engineers, and Clinicians
Publisher	Springer Nature
Pages	65-88
Number of pages	24
ISBN (Electronic)	9783031710674
ISBN (Print)	9783031710667
DOIs	https://doi.org/10.1007/978-3-031-71067-4_3
State	Published - Dec 24 2024

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© Springer Nature Switzerland AG 2010, 2024. All rights reserved.

Keywords

Cardiac action potential
Cardiac conduction
Cardiac electrical activity
Depolarization
Gap junctions
Repolarization

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10.1007/978-3-031-71067-4_3

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AU - Napotnik, Tina Batista

AU - Iaizzo, Paul A.

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N2 - It is the interplay between various ion channels within the membranes of cardiomyocytes that is responsible for depolarization and repolarization of the heart cells. Cell-to-cell coupling between myocytes is mediated via gap junction proteins and is involved in overall propagation of action potentials throughout the heart. In this chapter, different phases of the action potential of heart cells are discussed, and the role and characteristics of the most important ion channels that are active during these phases are conferred. Differences in the expressions of the various ion and gap junction channels under normal and certain pathological conditions are described.

AB - It is the interplay between various ion channels within the membranes of cardiomyocytes that is responsible for depolarization and repolarization of the heart cells. Cell-to-cell coupling between myocytes is mediated via gap junction proteins and is involved in overall propagation of action potentials throughout the heart. In this chapter, different phases of the action potential of heart cells are discussed, and the role and characteristics of the most important ion channels that are active during these phases are conferred. Differences in the expressions of the various ion and gap junction channels under normal and certain pathological conditions are described.

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KW - Cardiac conduction

KW - Cardiac electrical activity

KW - Depolarization

KW - Gap junctions

KW - Repolarization

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M3 - Chapter

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BT - Cardiac Electrophysiology Methods and Models

PB - Springer Nature

ER -

Cardiac action potentials, ion channels, and gap junctions

Abstract

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