Carcinogen biomarkers for lung or oral cancer chemoprevention trials.

Research output: Contribution to journalComment/debate

24 Citations (Scopus)

Abstract

The potential applicability of specific carcinogen-derived biomarkers in chemoprevention trials against lung and oral cancer is discussed. At present, there are no examples of the use of these biomarkers in chemoprevention trials, but the principle has been established in chemoprevention trials directed at aflatoxin B1-induced liver cancer. Polycyclic aromatic hydrocarbons (PAHs) and tobacco-specific nitrosamines are among the most important carcinogens invoked as causes of lung and oral cancer. Biomarkers that are potentially practical for current application in chemoprevention trials are 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-DNA adducts, as determined by HPLC with fluorescence detection, nitrosamino acids in urine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in urine, nicotine metabolites in urine, and metabolites of cytochrome P450 substrates in urine. Biomarkers that need further development or exploration before application in trials include 7-methylguanine in DNA, tobacco-specific nitrosamine-DNA adducts, acrolein/crotonaldehyde-DNA adducts, PAH-protein adducts, acetaldehyde-protein adducts, pyrene metabolites in urine and benzo[a]pyrene metabolites in urine. Such carcinogen derived-biomarkers could be applied in chemoprevention trials to test the hypothesis that chemopreventive agents alter carcinogen metabolic activation and detoxification and, ultimately, risk for cancer.

Original languageEnglish (US)
Pages (from-to)245-255
Number of pages11
JournalIARC scientific publications
Volume154
StatePublished - Jan 1 2001

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Mouth Neoplasms
Chemoprevention
Carcinogens
Lung Neoplasms
Biomarkers
Urine
Nitrosamines
2-butenal
DNA Adducts
Tobacco
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Acrolein
Aflatoxin B1
Acetaldehyde
Benzo(a)pyrene
Polycyclic Aromatic Hydrocarbons
Glucuronides
Liver Neoplasms
Nicotine
Cytochrome P-450 Enzyme System

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Carcinogen biomarkers for lung or oral cancer chemoprevention trials. / Hecht, Stephen S.

In: IARC scientific publications, Vol. 154, 01.01.2001, p. 245-255.

Research output: Contribution to journalComment/debate

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