Carbon nanotubes swine influenza (H1N1) virus sensors

Dongjin Lee; Yogesh Chander; Sagar M. Goyal; Tianhong Cui

doi:10.1115/IMECE2010-40735

Carbon nanotubes swine influenza (H1N1) virus sensors

Dongjin Lee
, Yogesh Chander
, Sagar M. Goyal
, Tianhong Cui

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a label-free detection of swine influenza virus (SIV) H1N1 by means of the excellent electrical properties of single-walled carbon nanotubes (SWCNTs). The electrical resistance of SWCNT resistor tends to increase upon the surface adsorption of macromolecules such as poly-L-lysine, anti-SIV antibodies, and SIVs in the process of immunoassay. The SWCNT network resistor was successfully able to detect as low as 180 TCID₅₀/ml of SIV using the resistance shifts upon immunobinding of SIVs. The sensor specificity was demonstrated against transmissible gastroenteritis virus (TGEV) and feline calicivirus (FCV). This facile CNT-based immnoassay has potential applications as a rapid point-of-care detection or a sensing platform for lab-on-a-chip systems.

Original language	English (US)
Title of host publication	Biomedical and Biotechnology Engineering
Publisher	American Society of Mechanical Engineers (ASME)
Pages	49-52
Number of pages	4
ISBN (Print)	9780791844267
DOIs	https://doi.org/10.1115/IMECE2010-40735
State	Published - 2010
Event	ASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010 - Vancouver, BC, Canada Duration: Nov 12 2010 → Nov 18 2010

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume	2

Conference

Conference	ASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010
Country/Territory	Canada
City	Vancouver, BC
Period	11/12/10 → 11/18/10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1115/IMECE2010-40735

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Carbon nanotubes swine influenza (H1N1) virus sensors. / Lee, Dongjin; Chander, Yogesh; Goyal, Sagar M. et al.
Biomedical and Biotechnology Engineering. American Society of Mechanical Engineers (ASME), 2010. p. 49-52 (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lee, D, Chander, Y, Goyal, SM & Cui, T 2010, Carbon nanotubes swine influenza (H1N1) virus sensors. in Biomedical and Biotechnology Engineering. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 2, American Society of Mechanical Engineers (ASME), pp. 49-52, ASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010, Vancouver, BC, Canada, 11/12/10. https://doi.org/10.1115/IMECE2010-40735

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title = "Carbon nanotubes swine influenza (H1N1) virus sensors",

abstract = "We present a label-free detection of swine influenza virus (SIV) H1N1 by means of the excellent electrical properties of single-walled carbon nanotubes (SWCNTs). The electrical resistance of SWCNT resistor tends to increase upon the surface adsorption of macromolecules such as poly-L-lysine, anti-SIV antibodies, and SIVs in the process of immunoassay. The SWCNT network resistor was successfully able to detect as low as 180 TCID50/ml of SIV using the resistance shifts upon immunobinding of SIVs. The sensor specificity was demonstrated against transmissible gastroenteritis virus (TGEV) and feline calicivirus (FCV). This facile CNT-based immnoassay has potential applications as a rapid point-of-care detection or a sensing platform for lab-on-a-chip systems.",

author = "Dongjin Lee and Yogesh Chander and Goyal, \{Sagar M.\} and Tianhong Cui",

year = "2010",

doi = "10.1115/IMECE2010-40735",

language = "English (US)",

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series = "ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)",

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AU - Lee, Dongjin

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AU - Goyal, Sagar M.

AU - Cui, Tianhong

PY - 2010

Y1 - 2010

N2 - We present a label-free detection of swine influenza virus (SIV) H1N1 by means of the excellent electrical properties of single-walled carbon nanotubes (SWCNTs). The electrical resistance of SWCNT resistor tends to increase upon the surface adsorption of macromolecules such as poly-L-lysine, anti-SIV antibodies, and SIVs in the process of immunoassay. The SWCNT network resistor was successfully able to detect as low as 180 TCID50/ml of SIV using the resistance shifts upon immunobinding of SIVs. The sensor specificity was demonstrated against transmissible gastroenteritis virus (TGEV) and feline calicivirus (FCV). This facile CNT-based immnoassay has potential applications as a rapid point-of-care detection or a sensing platform for lab-on-a-chip systems.

AB - We present a label-free detection of swine influenza virus (SIV) H1N1 by means of the excellent electrical properties of single-walled carbon nanotubes (SWCNTs). The electrical resistance of SWCNT resistor tends to increase upon the surface adsorption of macromolecules such as poly-L-lysine, anti-SIV antibodies, and SIVs in the process of immunoassay. The SWCNT network resistor was successfully able to detect as low as 180 TCID50/ml of SIV using the resistance shifts upon immunobinding of SIVs. The sensor specificity was demonstrated against transmissible gastroenteritis virus (TGEV) and feline calicivirus (FCV). This facile CNT-based immnoassay has potential applications as a rapid point-of-care detection or a sensing platform for lab-on-a-chip systems.

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T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)

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BT - Biomedical and Biotechnology Engineering

PB - American Society of Mechanical Engineers (ASME)

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ER -

Carbon nanotubes swine influenza (H1N1) virus sensors

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