A novel approach of using self-assembled monolayer (SAM) patterns of carbon nanotubes/nanowires as an efficient means to control the adhesion and shape of mesenchymal stem cells (MSN) has been proposed. The SAM patterns were used to direct the assembly of single-walled CNTs (swCNTs) and multi-walled CNTs (mwCNTs) on solid substrates. A self-limiting mechanism ensured the assembly of only a single layer of CNTs without significant change of surface morphology. The MSCs exhibited preferential growth on CNT patterns, and it was also observed that the CNT patterns did not have a harmful effect on the MSCs. High density swCNT patterns between electrodes were also fabricated to demonstrate the growth of MSCs on the electrodes. The development of directed MSC growth on patterned CNTs offers opportunities to use these nanostructure-based surface arrays as high-throughput cell assay tools and as functional scaffolds for tailoring the MSCs' environment to induce the desired stem cell morphology.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Sep 17 2007|