Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells

Sung Young Park, Sun Young Park, Seon Namgung, Byeongju Kim, Jiwoon Im, Ji Youn Kim, Kyung Sun, Kyu Back Lee, Jwa Min Nam, Yongdoo Park, Seunghun Hong

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A novel approach of using self-assembled monolayer (SAM) patterns of carbon nanotubes/nanowires as an efficient means to control the adhesion and shape of mesenchymal stem cells (MSN) has been proposed. The SAM patterns were used to direct the assembly of single-walled CNTs (swCNTs) and multi-walled CNTs (mwCNTs) on solid substrates. A self-limiting mechanism ensured the assembly of only a single layer of CNTs without significant change of surface morphology. The MSCs exhibited preferential growth on CNT patterns, and it was also observed that the CNT patterns did not have a harmful effect on the MSCs. High density swCNT patterns between electrodes were also fabricated to demonstrate the growth of MSCs on the electrodes. The development of directed MSC growth on patterned CNTs offers opportunities to use these nanostructure-based surface arrays as high-throughput cell assay tools and as functional scaffolds for tailoring the MSCs' environment to induce the desired stem cell morphology.

Original languageEnglish (US)
Pages (from-to)2530-2534
Number of pages5
JournalAdvanced Materials
Volume19
Issue number18
DOIs
StatePublished - Sep 17 2007

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Carbon Nanotubes
Stem cells
Monolayers
Carbon nanotubes
Self assembled monolayers
Electrodes
Scaffolds
Nanowires
Surface morphology
Assays
Nanostructures
Adhesion
Throughput
Substrates

Cite this

Park, S. Y., Park, S. Y., Namgung, S., Kim, B., Im, J., Kim, J. Y., ... Hong, S. (2007). Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells. Advanced Materials, 19(18), 2530-2534. https://doi.org/10.1002/adma.200600875

Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells. / Park, Sung Young; Park, Sun Young; Namgung, Seon; Kim, Byeongju; Im, Jiwoon; Kim, Ji Youn; Sun, Kyung; Lee, Kyu Back; Nam, Jwa Min; Park, Yongdoo; Hong, Seunghun.

In: Advanced Materials, Vol. 19, No. 18, 17.09.2007, p. 2530-2534.

Research output: Contribution to journalArticle

Park, SY, Park, SY, Namgung, S, Kim, B, Im, J, Kim, JY, Sun, K, Lee, KB, Nam, JM, Park, Y & Hong, S 2007, 'Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells', Advanced Materials, vol. 19, no. 18, pp. 2530-2534. https://doi.org/10.1002/adma.200600875
Park, Sung Young ; Park, Sun Young ; Namgung, Seon ; Kim, Byeongju ; Im, Jiwoon ; Kim, Ji Youn ; Sun, Kyung ; Lee, Kyu Back ; Nam, Jwa Min ; Park, Yongdoo ; Hong, Seunghun. / Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells. In: Advanced Materials. 2007 ; Vol. 19, No. 18. pp. 2530-2534.
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