Abstract
A selection of carbon-fluorine bond-forming reactions is presented with particular focus on transition-metal-mediated fluorination. A brief summary of conventional fluorination reactions is followed by a discussion of fluorination reactions mediated by palladium and silver. Investigations into the mechanism as well as the conceptual difficulty associated with transition-metal-mediated carbon-fluorine bond formation are presented. 1 Introduction 2 Nucleophilic Fluorination 3 Electrophilic Fluorination 4 Balz-Schiemann Reaction 5 Palladium-Mediated C-X Bond Formation 6 Palladium-Mediated Nucleophilic Fluorination 7 Palladium-Mediated Directed Electrophilic Fluorination 8 Palladium-Mediated Electrophilic Fluorination 9 Silver-Mediated Fluorination 10 Conclusion.
| Original language | English (US) |
|---|---|
| Article number | C00210SS |
| Pages (from-to) | 1804-1821 |
| Number of pages | 18 |
| Journal | Synthesis |
| Issue number | 11 |
| DOIs | |
| State | Published - 2010 |
| Externally published | Yes |
Keywords
- Carbon-fluorine bond formation
- Catalysis
- Palladium
- Silver
- Transition metals