Carbon-fluorine bond formation for the synthesis of aryl fluorides

Takeru Furuya, Johannes E.M.N. Klein, Tobias Ritter

Research output: Contribution to journalReview articlepeer-review

191 Scopus citations


A selection of carbon-fluorine bond-forming reactions is presented with particular focus on transition-metal-mediated fluorination. A brief summary of conventional fluorination reactions is followed by a discussion of fluorination reactions mediated by palladium and silver. Investigations into the mechanism as well as the conceptual difficulty associated with transition-metal-mediated carbon-fluorine bond formation are presented. 1 Introduction 2 Nucleophilic Fluorination 3 Electrophilic Fluorination 4 Balz-Schiemann Reaction 5 Palladium-Mediated C-X Bond Formation 6 Palladium-Mediated Nucleophilic Fluorination 7 Palladium-Mediated Directed Electrophilic Fluorination 8 Palladium-Mediated Electrophilic Fluorination 9 Silver-Mediated Fluorination 10 Conclusion.

Original languageEnglish (US)
Article numberC00210SS
Pages (from-to)1804-1821
Number of pages18
Issue number11
StatePublished - 2010
Externally publishedYes


  • Carbon-fluorine bond formation
  • Catalysis
  • Palladium
  • Silver
  • Transition metals


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