Carbon-13 and Nitrogen-15 Spin-Lattice Relaxation (T1) and Nuclear Overhauser Enhancement (NOE) Measurements for Acetamide and N,N-Dimethylacetamide

Donald D. Giannini; Ian M. Armitage; Harry Pearson; David M. Grant; John D. Roberts

doi:10.1021/ja00845a023

Carbon-13 and Nitrogen-15 Spin-Lattice Relaxation (T₁) and Nuclear Overhauser Enhancement (NOE) Measurements for Acetamide and N,N-Dimethylacetamide

Donald D. Giannini
, Ian M. Armitage
, Harry Pearson
, David M. Grant
, John D. Roberts

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Nitrogen-15 spin-lattice relaxation times (T₁'s) and nuclear Overhauser enhancement (NOE) values are found to vary over a range of concentrations for acetamide. Our data indicate that intermolecular amide-amide hydrogen bonds are broken on dilution in water. Carbon-13 spin-lattice relaxation times and nuclear Overhauser enhancement measurements are given for acetamide and N,N-dimethylacetamide at 5.3 M. There is good agreement between experimental and calculated relaxation rates assuming rapid rotation of the α-methyl group and slow rotation about the amide bond.

Original language	English (US)
Pages (from-to)	3416-3419
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	97
Issue number	12
DOIs	https://doi.org/10.1021/ja00845a023
State	Published - Jun 1 1975
Externally published	Yes

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title = "Carbon-13 and Nitrogen-15 Spin-Lattice Relaxation (T1) and Nuclear Overhauser Enhancement (NOE) Measurements for Acetamide and N,N-Dimethylacetamide",

abstract = "Nitrogen-15 spin-lattice relaxation times (T1's) and nuclear Overhauser enhancement (NOE) values are found to vary over a range of concentrations for acetamide. Our data indicate that intermolecular amide-amide hydrogen bonds are broken on dilution in water. Carbon-13 spin-lattice relaxation times and nuclear Overhauser enhancement measurements are given for acetamide and N,N-dimethylacetamide at 5.3 M. There is good agreement between experimental and calculated relaxation rates assuming rapid rotation of the α-methyl group and slow rotation about the amide bond.",

author = "Giannini, \{Donald D.\} and Armitage, \{Ian M.\} and Harry Pearson and Grant, \{David M.\} and Roberts, \{John D.\}",

year = "1975",

month = jun,

day = "1",

doi = "10.1021/ja00845a023",

language = "English (US)",

volume = "97",

pages = "3416--3419",

journal = "Journal of the American Chemical Society",

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TY - JOUR

T1 - Carbon-13 and Nitrogen-15 Spin-Lattice Relaxation (T1) and Nuclear Overhauser Enhancement (NOE) Measurements for Acetamide and N,N-Dimethylacetamide

AU - Giannini, Donald D.

AU - Armitage, Ian M.

AU - Pearson, Harry

AU - Grant, David M.

AU - Roberts, John D.

PY - 1975/6/1

Y1 - 1975/6/1

N2 - Nitrogen-15 spin-lattice relaxation times (T1's) and nuclear Overhauser enhancement (NOE) values are found to vary over a range of concentrations for acetamide. Our data indicate that intermolecular amide-amide hydrogen bonds are broken on dilution in water. Carbon-13 spin-lattice relaxation times and nuclear Overhauser enhancement measurements are given for acetamide and N,N-dimethylacetamide at 5.3 M. There is good agreement between experimental and calculated relaxation rates assuming rapid rotation of the α-methyl group and slow rotation about the amide bond.

AB - Nitrogen-15 spin-lattice relaxation times (T1's) and nuclear Overhauser enhancement (NOE) values are found to vary over a range of concentrations for acetamide. Our data indicate that intermolecular amide-amide hydrogen bonds are broken on dilution in water. Carbon-13 spin-lattice relaxation times and nuclear Overhauser enhancement measurements are given for acetamide and N,N-dimethylacetamide at 5.3 M. There is good agreement between experimental and calculated relaxation rates assuming rapid rotation of the α-methyl group and slow rotation about the amide bond.

UR - https://www.scopus.com/pages/publications/0011701425

UR - https://www.scopus.com/pages/publications/0011701425#tab=citedBy

U2 - 10.1021/ja00845a023

DO - 10.1021/ja00845a023

M3 - Article

AN - SCOPUS:0011701425

SN - 0002-7863

VL - 97

SP - 3416

EP - 3419

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 12

ER -

Carbon-13 and Nitrogen-15 Spin-Lattice Relaxation (T₁) and Nuclear Overhauser Enhancement (NOE) Measurements for Acetamide and N,N-Dimethylacetamide

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