Chemical heterogeneity on biomaterial surfaces can transform its interfacial properties, rendering nanoscale heterogeneity profoundly consequential during bioadhesion. To examine the role played by chemical heterogeneity in the adsorption of viruses on synthetic surfaces, a range of novel coatings is developed wherein a tunable mixture of electrostatic tethers for viral binding, and carbohydrate brushes, bearing pendant α-mannose, β-galactose, or β-glucose groups, is incorporated. The effects of binding site density, brush composition, and brush architecture on viral adsorption, with the goal of formulating design specifications for virus-resistant coatings are experimentally evaluated. It is concluded that virus-coating interactions are shaped by the interplay between brush architecture and binding site density, after quantifying the adsorption of adenoviruses, influenza, and fibrinogen on a library of carbohydrate brushes co-immobilized with different ratios of binding sites. These insights will be of utility in guiding the design of polymer coatings in realistic settings where they will be populated with defects.
|Original language||English (US)|
|Journal||Macromolecular Rapid Communications|
|State||Published - Jan 2019|
Bibliographical noteFunding Information:
The authors acknowledge the Defense Threat Reduction Agency (DTRA) for the funding provided through grant HDTRA1-12-1-0039 as a part of the interfacial dynamics and reactivity program. The authors gratefully acknowledge the Engineering Research Centers Program of the National Science Foundation for funding provided through award EEC-1647837. R.K. gratefully acknowledges Rackham Graduate School for providing financial support through the Rackham Predoctoral Fellowship.
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- carbohydrate brushes
- glycopolymer brushes
- viral adsorption