Carbohydrate-Based Polymer Brushes Prevent Viral Adsorption on Electrostatically Heterogeneous Interfaces

Ramya Kumar, Domenic Kratzer, Kenneth Cheng, Julia Prisby, James Sugai, William V. Giannobile, Joerg Lahann

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Chemical heterogeneity on biomaterial surfaces can transform its interfacial properties, rendering nanoscale heterogeneity profoundly consequential during bioadhesion. To examine the role played by chemical heterogeneity in the adsorption of viruses on synthetic surfaces, a range of novel coatings is developed wherein a tunable mixture of electrostatic tethers for viral binding, and carbohydrate brushes, bearing pendant α-mannose, β-galactose, or β-glucose groups, is incorporated. The effects of binding site density, brush composition, and brush architecture on viral adsorption, with the goal of formulating design specifications for virus-resistant coatings are experimentally evaluated. It is concluded that virus-coating interactions are shaped by the interplay between brush architecture and binding site density, after quantifying the adsorption of adenoviruses, influenza, and fibrinogen on a library of carbohydrate brushes co-immobilized with different ratios of binding sites. These insights will be of utility in guiding the design of polymer coatings in realistic settings where they will be populated with defects.

Original languageEnglish (US)
Article number1800530
JournalMacromolecular Rapid Communications
Issue number1
StatePublished - Jan 2019

Bibliographical note

Funding Information:
The authors acknowledge the Defense Threat Reduction Agency (DTRA) for the funding provided through grant HDTRA1-12-1-0039 as a part of the interfacial dynamics and reactivity program. The authors gratefully acknowledge the Engineering Research Centers Program of the National Science Foundation for funding provided through award EEC-1647837. R.K. gratefully acknowledges Rackham Graduate School for providing financial support through the Rackham Predoctoral Fellowship.

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • QCM
  • adenovirus
  • bioadhesion
  • carbohydrate brushes
  • glycopolymer brushes
  • influenza
  • viral adsorption


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