Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs

Robert Vince; Susan Daluge; Heejoo Lee; William M. Shannon; Gussie Arnett; Thomas W. Schafer; Tattanahalli L. Nagabhushan; Paul Reichert; Hsingan Tsai

doi:10.1126/science.6684328

Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs

Robert Vince
, Susan Daluge
, Heejoo Lee
, William M. Shannon
, Gussie Arnett
, Thomas W. Schafer
, Tattanahalli L. Nagabhushan
, Paul Reichert
, Hsingan Tsai

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

Original language	English (US)
Pages (from-to)	1405-1406
Number of pages	2
Journal	Science
Volume	221
Issue number	4618
DOIs	https://doi.org/10.1126/science.6684328
State	Published - 1983

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title = "Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs",

abstract = "Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.",

author = "Robert Vince and Susan Daluge and Heejoo Lee and Shannon, \{William M.\} and Gussie Arnett and Schafer, \{Thomas W.\} and Nagabhushan, \{Tattanahalli L.\} and Paul Reichert and Hsingan Tsai",

year = "1983",

doi = "10.1126/science.6684328",

language = "English (US)",

volume = "221",

pages = "1405--1406",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4618",

}

TY - JOUR

T1 - Carbocyclic arabinofuranosyladenine (cyclaradine)

T2 - Efficacy against genital herpes in guinea pigs

AU - Vince, Robert

AU - Daluge, Susan

AU - Lee, Heejoo

AU - Shannon, William M.

AU - Arnett, Gussie

AU - Schafer, Thomas W.

AU - Nagabhushan, Tattanahalli L.

AU - Reichert, Paul

AU - Tsai, Hsingan

PY - 1983

Y1 - 1983

N2 - Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

AB - Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

UR - https://www.scopus.com/pages/publications/0020525820

UR - https://www.scopus.com/pages/publications/0020525820#tab=citedBy

U2 - 10.1126/science.6684328

DO - 10.1126/science.6684328

M3 - Article

C2 - 6684328

AN - SCOPUS:0020525820

SN - 0036-8075

VL - 221

SP - 1405

EP - 1406

JO - Science

JF - Science

IS - 4618

ER -

Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs

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