Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs

Robert Vince, Susan Daluge, Heejoo Lee, William M. Shannon, Gussie Arnett, Thomas W. Schafer, Tattanahalli L. Nagabhushan, Paul Reichert, Hsingan Tsai

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

Original languageEnglish (US)
Pages (from-to)1405-1406
Number of pages2
JournalScience
Volume221
Issue number4618
DOIs
StatePublished - 1983

Fingerprint Dive into the research topics of 'Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs'. Together they form a unique fingerprint.

Cite this