Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs

Robert Vince; Susan Daluge; Heejoo Lee; William M. Shannon; Gussie Arnett; Thomas W. Schafer; Tattanahalli L. Nagabhushan; Paul Reichert; Hsingan Tsai

doi:10.1126/science.6684328

Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs

Robert Vince, Susan Daluge, Heejoo Lee, William M. Shannon, Gussie Arnett, Thomas W. Schafer, Tattanahalli L. Nagabhushan, Paul Reichert, Hsingan Tsai

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

Original language	English (US)
Pages (from-to)	1405-1406
Number of pages	2
Journal	Science
Volume	221
Issue number	4618
DOIs	https://doi.org/10.1126/science.6684328
State	Published - 1983

Access

10.1126/science.6684328

Fingerprint Dive into the research topics of 'Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs'. Together they form a unique fingerprint.

Cite this

Carbocyclic arabinofuranosyladenine (cyclaradine) : Efficacy against genital herpes in guinea pigs. / Vince, Robert; Daluge, Susan; Lee, Heejoo; Shannon, William M.; Arnett, Gussie; Schafer, Thomas W.; Nagabhushan, Tattanahalli L.; Reichert, Paul; Tsai, Hsingan.

In: Science, Vol. 221, No. 4618, 1983, p. 1405-1406.

Research output: Contribution to journal › Article › peer-review

@article{661c35099b1a450483a00ad6b00c4c70,

title = "Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs",

abstract = "Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.",

author = "Robert Vince and Susan Daluge and Heejoo Lee and Shannon, {William M.} and Gussie Arnett and Schafer, {Thomas W.} and Nagabhushan, {Tattanahalli L.} and Paul Reichert and Hsingan Tsai",

year = "1983",

doi = "10.1126/science.6684328",

language = "English (US)",

volume = "221",

pages = "1405--1406",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4618",

}

TY - JOUR

T1 - Carbocyclic arabinofuranosyladenine (cyclaradine)

T2 - Efficacy against genital herpes in guinea pigs

AU - Vince, Robert

AU - Daluge, Susan

AU - Lee, Heejoo

AU - Shannon, William M.

AU - Arnett, Gussie

AU - Schafer, Thomas W.

AU - Nagabhushan, Tattanahalli L.

AU - Reichert, Paul

AU - Tsai, Hsingan

PY - 1983

Y1 - 1983

N2 - Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

AB - Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.

UR - http://www.scopus.com/inward/record.url?scp=0020525820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020525820&partnerID=8YFLogxK

U2 - 10.1126/science.6684328

DO - 10.1126/science.6684328

M3 - Article

C2 - 6684328

AN - SCOPUS:0020525820

VL - 221

SP - 1405

EP - 1406

JO - Science

JF - Science

SN - 0036-8075

IS - 4618

ER -

Carbocyclic arabinofuranosyladenine (cyclaradine): Efficacy against genital herpes in guinea pigs

Abstract

Access

Other files and links

Cite this