Carbocyclic analogs of arabinosylpurine nucleosides

Carbocyclic analogs of arabinofuranosylguanine (VII) and 2,6‐diamino‐9‐β‐arabinofuranosylpurine (VIII) and the corresponding 8‐azapurine analogs, 5‐amino‐7‐hydroxy‐3‐[2α,3β‐dihydroxy‐4α‐(hydroxymethyl)cyclopent‐1α‐yl]‐v‐triazolo[4,5‐d]pyrimidine (X) and 5,7‐diamino‐3‐[2α,3β‐dihydroxy‐4α‐(hydroxymethyl)cyclopent‐1α‐yl]‐v‐triazolo[4,5‐d]pyrimidine (XI), were prepared. Carbocyclic nucleoside analogs VII and × exhibited significant cytotoxicity against P‐388 mouse leukemia cells in culture. In vitro testing against herpes simplex type 1 (strain HF) indicated that only VIII exhibited significant antiviral activity.