Carbocyclic analogs of arabinosylpurine nucleosides

Heejoo Lee, Robert Vince

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Carbocyclic analogs of arabinofuranosylguanine (VII) and 2,6‐diamino‐9‐β‐arabinofuranosylpurine (VIII) and the corresponding 8‐azapurine analogs, 5‐amino‐7‐hydroxy‐3‐[2α,3β‐dihydroxy‐4α‐(hydroxymethyl)cyclopent‐1α‐yl]‐v‐triazolo[4,5‐d]pyrimidine (X) and 5,7‐diamino‐3‐[2α,3β‐dihydroxy‐4α‐(hydroxymethyl)cyclopent‐1α‐yl]‐v‐triazolo[4,5‐d]pyrimidine (XI), were prepared. Carbocyclic nucleoside analogs VII and × exhibited significant cytotoxicity against P‐388 mouse leukemia cells in culture. In vitro testing against herpes simplex type 1 (strain HF) indicated that only VIII exhibited significant antiviral activity.

Original languageEnglish (US)
Pages (from-to)1019-1021
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume69
Issue number9
DOIs
StatePublished - Sep 1980

Keywords

  • Antitumor activity—carbocyclic analogs of arabinosylpurine nucleosides, synthesis and testing
  • Antiviral activity—carbocyclic analogs of arabinosylpurine nucleosides, synthesis and testing
  • Arabinosylpurine nucleosides—Carbocyclic analogs, synthesis and evaluation for antitumor and antiviral activity

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