Capturing exchange using periodic radiofrequency irradiation

Timo Liimatainen, Hanne Laakso, Djaudat S Idiyatullin, Silvia Mangia, Shalom Michaeli

Research output: Contribution to journalArticle

Abstract

The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalJournal of Magnetic Resonance
Volume296
DOIs
StatePublished - Nov 1 2018

Fingerprint

Rate constants
Irradiation
irradiation
Proteins
sweep frequency
Chemical shift
Magnetic resonance imaging
chemical equilibrium
Magnetization
proteins
magnetization
pulses

Keywords

  • Bloch - McConnell equations
  • Chemical exchange
  • Periodic RF irradiation
  • RAFFn

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

Cite this

Capturing exchange using periodic radiofrequency irradiation. / Liimatainen, Timo; Laakso, Hanne; Idiyatullin, Djaudat S; Mangia, Silvia; Michaeli, Shalom.

In: Journal of Magnetic Resonance, Vol. 296, 01.11.2018, p. 79-84.

Research output: Contribution to journalArticle

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