Abstract
The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.
Original language | English (US) |
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Pages (from-to) | 79-84 |
Number of pages | 6 |
Journal | Journal of Magnetic Resonance |
Volume | 296 |
DOIs | |
State | Published - Nov 2018 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Inc.
Keywords
- Bloch - McConnell equations
- Chemical exchange
- Periodic RF irradiation
- RAFFn