Abstract
The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 79-84 |
| Number of pages | 6 |
| Journal | Journal of Magnetic Resonance |
| Volume | 296 |
| DOIs | |
| State | Published - Nov 2018 |
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Keywords
- Bloch - McConnell equations
- Chemical exchange
- Periodic RF irradiation
- RAFFn
Cite this
Capturing exchange using periodic radiofrequency irradiation. / Liimatainen, Timo; Laakso, Hanne; Idiyatullin, Djaudat; Mangia, Silvia; Michaeli, Shalom.
In: Journal of Magnetic Resonance, Vol. 296, 11.2018, p. 79-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Capturing exchange using periodic radiofrequency irradiation
AU - Liimatainen, Timo
AU - Laakso, Hanne
AU - Idiyatullin, Djaudat
AU - Mangia, Silvia
AU - Michaeli, Shalom
PY - 2018/11
Y1 - 2018/11
N2 - The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.
AB - The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.
KW - Bloch - McConnell equations
KW - Chemical exchange
KW - Periodic RF irradiation
KW - RAFFn
UR - http://www.scopus.com/inward/record.url?scp=85053183851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053183851&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2018.09.001
DO - 10.1016/j.jmr.2018.09.001
M3 - Article
C2 - 30223154
AN - SCOPUS:85053183851
VL - 296
SP - 79
EP - 84
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
SN - 1090-7807
ER -