Capturing exchange using periodic radiofrequency irradiation

Timo Liimatainen; Hanne Laakso; Djaudat Idiyatullin; Silvia Mangia; Shalom Michaeli

doi:10.1016/j.jmr.2018.09.001

Capturing exchange using periodic radiofrequency irradiation

Timo Liimatainen, Hanne Laakso, Djaudat Idiyatullin, Silvia Mangia, Shalom Michaeli

Center for Magnetic Resonance Research

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.

Original language	English (US)
Pages (from-to)	79-84
Number of pages	6
Journal	Journal of Magnetic Resonance
Volume	296
DOIs	https://doi.org/10.1016/j.jmr.2018.09.001
State	Published - Nov 2018

Bibliographical note

Funding Information:
The authors would like to thank following funding sources for financial support Instrumentarium Science Foundation (HL) , EU H2020 Marie Skłodowska RISE project #691110 (MICROBRADAM), Academy of Finland grants #275453 and #298007 , NIH grants U01-NS103569 , 1R01AG055591 , BTRC , P41 EB015894 , P30 NS057091 . SM was supported by Fulbright-Saastamoinen Foundation Grant in Health and Environmental Science.

Keywords

Bloch - McConnell equations
Chemical exchange
Periodic RF irradiation
RAFFn

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10.1016/j.jmr.2018.09.001

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661253

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@article{b03cd08633374dccbf4078f550bc59ab,

title = "Capturing exchange using periodic radiofrequency irradiation",

abstract = "The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.",

keywords = "Bloch - McConnell equations, Chemical exchange, Periodic RF irradiation, RAFFn",

author = "Timo Liimatainen and Hanne Laakso and Djaudat Idiyatullin and Silvia Mangia and Shalom Michaeli",

note = "Funding Information: The authors would like to thank following funding sources for financial support Instrumentarium Science Foundation (HL) , EU H2020 Marie Sk{\l}odowska RISE project #691110 (MICROBRADAM), Academy of Finland grants #275453 and #298007 , NIH grants U01-NS103569 , 1R01AG055591 , BTRC , P41 EB015894 , P30 NS057091 . SM was supported by Fulbright-Saastamoinen Foundation Grant in Health and Environmental Science.",

year = "2018",

month = nov,

doi = "10.1016/j.jmr.2018.09.001",

language = "English (US)",

volume = "296",

pages = "79--84",

journal = "Journal of Magnetic Resonance",

issn = "1090-7807",

publisher = "Academic Press Inc.",

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T1 - Capturing exchange using periodic radiofrequency irradiation

AU - Liimatainen, Timo

AU - Laakso, Hanne

AU - Idiyatullin, Djaudat

AU - Mangia, Silvia

AU - Michaeli, Shalom

N1 - Funding Information: The authors would like to thank following funding sources for financial support Instrumentarium Science Foundation (HL) , EU H2020 Marie Skłodowska RISE project #691110 (MICROBRADAM), Academy of Finland grants #275453 and #298007 , NIH grants U01-NS103569 , 1R01AG055591 , BTRC , P41 EB015894 , P30 NS057091 . SM was supported by Fulbright-Saastamoinen Foundation Grant in Health and Environmental Science.

PY - 2018/11

Y1 - 2018/11

N2 - The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.

AB - The dynamics of spin system coupled by chemical exchange between two sites with different chemical shifts during periodic radiofrequency (RF) irradiation was here investigated. When the instantaneous π-flip of effective frequency during the course of frequency sweep was applied, a significant increase of exchange-induced relaxation rate constants was observed for small tip angle of magnetization in the laboratory frame of reference. This increase of the rate constants corresponds to the side bands generated by the periodic irradiation during the RF pulses. The exchange - induced relaxation rate constants depend on the exchange conditions, the RF power and the irradiation period. The described phenomenon promises applications for studying protein dynamics and for generating exchange specific relaxation contrasts in MRI.

KW - Bloch - McConnell equations

KW - Chemical exchange

KW - Periodic RF irradiation

KW - RAFFn

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JO - Journal of Magnetic Resonance

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