Cannibalism, cell survival, and endocrine resistance in breast cancer

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Abstract

Breast cancer cells often respond to an endocrine therapy by altering expression of specific estrogen-responsive genes and inducing autophagy, a cannibalistic lysosomal pathway. Autophagy eliminates damaged or other organelles, allowing the recovery of the energy stored in their macromolecules to attempt restoration of metabolic homeostasis. Induction of autophagy can result from activation of the unfolded protein response following metabolic stress, the final cell fate often being determined by the extent and duration of autophagy. A study by Gonzalez-Malerva and colleagues builds upon this extensive knowledge, adding HSPB8 to the list of altered genes associated with endocrine resistance in breast cancer and describing the ability of HSPB8 to regulate autophagy and confer tamoxifen resistance.

Original languageEnglish (US)
Article number311
JournalBreast Cancer Research
Volume13
Issue number4
DOIs
StatePublished - Aug 12 2011
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2011 BioMed Central Ltd.

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