Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series

M. H.N. Chagas; A. L. Eckeli; A. W. Zuardi; M. A. Pena-Pereira; M. A. Sobreira-Neto; E. T. Sobreira; M. R. Camilo; M. M. Bergamaschi; C. H. Schenck; J. E.C. Hallak; V. Tumas; J. A.S. Crippa

doi:10.1111/jcpt.12179

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series

M. H.N. Chagas, A. L. Eckeli, A. W. Zuardi, M. A. Pena-Pereira, M. A. Sobreira-Neto, E. T. Sobreira, M. R. Camilo, M. M. Bergamaschi, C. H. Schenck, J. E.C. Hallak, V. Tumas, J. A.S. Crippa

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Abstract

What is known and objective Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in patients with Parkinson's disease. Cases summary Four patients treated with CBD had prompt and substantial reduction in the frequency of RBD-related events without side effects. What is new and conclusion This case series indicates that CBD is able to control the symptoms of RBD.

Original language	English (US)
Pages (from-to)	564-566
Number of pages	3
Journal	Journal of Clinical Pharmacy and Therapeutics
Volume	39
Issue number	5
DOIs	https://doi.org/10.1111/jcpt.12179
State	Published - Oct 2014
Externally published	Yes

Keywords

Parkinson's disease
cannabidiol
rapid eye movement sleep behaviour disorder

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10.1111/jcpt.12179

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Chagas, M. H. N., Eckeli, A. L., Zuardi, A. W., Pena-Pereira, M. A., Sobreira-Neto, M. A., Sobreira, E. T., Camilo, M. R., Bergamaschi, M. M., Schenck, C. H., Hallak, J. E. C., Tumas, V., & Crippa, J. A. S. (2014). Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series. Journal of Clinical Pharmacy and Therapeutics, 39(5), 564-566. https://doi.org/10.1111/jcpt.12179

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series. / Chagas, M. H.N.; Eckeli, A. L.; Zuardi, A. W. et al.
In: Journal of Clinical Pharmacy and Therapeutics, Vol. 39, No. 5, 10.2014, p. 564-566.

Research output: Contribution to journal › Article › peer-review

Chagas, MHN, Eckeli, AL, Zuardi, AW, Pena-Pereira, MA, Sobreira-Neto, MA, Sobreira, ET, Camilo, MR, Bergamaschi, MM, Schenck, CH, Hallak, JEC, Tumas, V & Crippa, JAS 2014, 'Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series', Journal of Clinical Pharmacy and Therapeutics, vol. 39, no. 5, pp. 564-566. https://doi.org/10.1111/jcpt.12179

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abstract = "What is known and objective Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in patients with Parkinson's disease. Cases summary Four patients treated with CBD had prompt and substantial reduction in the frequency of RBD-related events without side effects. What is new and conclusion This case series indicates that CBD is able to control the symptoms of RBD.",

keywords = "Parkinson's disease, cannabidiol, rapid eye movement sleep behaviour disorder",

author = "Chagas, {M. H.N.} and Eckeli, {A. L.} and Zuardi, {A. W.} and Pena-Pereira, {M. A.} and Sobreira-Neto, {M. A.} and Sobreira, {E. T.} and Camilo, {M. R.} and Bergamaschi, {M. M.} and Schenck, {C. H.} and Hallak, {J. E.C.} and V. Tumas and Crippa, {J. A.S.}",

year = "2014",

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AU - Chagas, M. H.N.

AU - Eckeli, A. L.

AU - Zuardi, A. W.

AU - Pena-Pereira, M. A.

AU - Sobreira-Neto, M. A.

AU - Sobreira, E. T.

AU - Camilo, M. R.

AU - Bergamaschi, M. M.

AU - Schenck, C. H.

AU - Hallak, J. E.C.

AU - Tumas, V.

AU - Crippa, J. A.S.

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AB - What is known and objective Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in patients with Parkinson's disease. Cases summary Four patients treated with CBD had prompt and substantial reduction in the frequency of RBD-related events without side effects. What is new and conclusion This case series indicates that CBD is able to control the symptoms of RBD.

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Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series

Abstract

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