Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series

M. H.N. Chagas, A. L. Eckeli, A. W. Zuardi, M. A. Pena-Pereira, M. A. Sobreira-Neto, E. T. Sobreira, M. R. Camilo, M. M. Bergamaschi, C. H. Schenck, J. E.C. Hallak, V. Tumas, J. A.S. Crippa

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Abstract

What is known and objective Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in patients with Parkinson's disease. Cases summary Four patients treated with CBD had prompt and substantial reduction in the frequency of RBD-related events without side effects. What is new and conclusion This case series indicates that CBD is able to control the symptoms of RBD.

Original languageEnglish (US)
Pages (from-to)564-566
Number of pages3
JournalJournal of Clinical Pharmacy and Therapeutics
Volume39
Issue number5
DOIs
StatePublished - Oct 2014

Keywords

  • Parkinson's disease
  • cannabidiol
  • rapid eye movement sleep behaviour disorder

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    Chagas, M. H. N., Eckeli, A. L., Zuardi, A. W., Pena-Pereira, M. A., Sobreira-Neto, M. A., Sobreira, E. T., Camilo, M. R., Bergamaschi, M. M., Schenck, C. H., Hallak, J. E. C., Tumas, V., & Crippa, J. A. S. (2014). Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: A case series. Journal of Clinical Pharmacy and Therapeutics, 39(5), 564-566. https://doi.org/10.1111/jcpt.12179