Canine epilepsy: An underutilized model

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23 Scopus citations

Abstract

The mainstay of comparative research for epilepsy has been rodent models of induced epilepsy. This rodent basic science is essential, but it does not always translate to similar results in people, likely because induced epilepsy is not always similar enough to naturally occurring epilepsy. A good large animal, intermediate model would be very helpful to potentially bridge this translational gap. Epilepsy is the most common medical neurologic disease of dogs. It has been proposed since the 1970s that dogs with naturally occurring epilepsy could potentially be used as a comparative model for people of the underlying basis and therapy of epilepsy. There have been sporadic studies in the decades since then, with a relative surge in the last 10 years. These canine studies in the areas of genetics, drug therapy, dietary therapy, electroencelphalogram research, and devices for epilepsy show proof of concept that canine epilepsy can be a very good model for comparative research for many, but not all, facets of epilepsy. Results of research in canine epilepsy can and have benefited the improvement of treatment for both people and dogs.

Original languageEnglish (US)
Article numberilu021
Pages (from-to)182-186
Number of pages5
JournalILAR Journal
Volume55
Issue number1
DOIs
StatePublished - Jul 2014

Keywords

  • Canine
  • Device
  • Drugs
  • EEG
  • Epilepsy
  • Model
  • Seizure

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