Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation

E. S. Ebbini; R. Seip; L. Iasemidis; M. O'Donnell; C. A. Cain

doi:10.1109/IEMBS.1992.5761000

Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation

E. S. Ebbini, R. Seip, L. Iasemidis, M. O'Donnell, C. A. Cain

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A system with combined therapy/imaging capability for noninvasive lesion formation in tissue using high-intensity focused ultrasound will be presented. The system combines a highly focused therapeutic device with an imaging transducer for monitoring the treated volume in realtime using signal processing algorithms of ultrasound radio frequency (RF) echo data. Preliminary results indicate that it is feasible to distinguish between reversible and irreversible change in the state of the tissue due to high-intensity focused ultrasound. An autoregressive model has been assumed for processing echo data from the treated region. The reflection coefficients for a low-order AR model are calculated from A-line data taken during the treatment (every 1 to 2 seconds). The contours of the reflection coefficients can be used to distinguish between reversible and irreversible change in the state of the tissue. Noninvasive quantitative measures of thresholds for irreversible tissue damage based on the AR reflection coefficients are currently being investigated. Experimental results from our investigation will be presented. In addition, a review of the current status of research on tissue ablation using high-intensity focused ultrasound will be given.

Original language	English (US)
Title of host publication	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Editors	Jean Pierre Morucci, Robert Plonsey, Swamy Laxminarayan, Jean Louis Coatrieux
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	352-353
Number of pages	2
ISBN (Electronic)	0780307852
DOIs	https://doi.org/10.1109/IEMBS.1992.5761000
State	Published - Jan 1 1992
Externally published	Yes
Event	14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 - Paris, France Duration: Oct 29 1992 → Nov 1 1992

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	1
ISSN (Print)	1557-170X

Conference

Conference	14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Country	France
City	Paris
Period	10/29/92 → 11/1/92

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1109/IEMBS.1992.5761000

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Ebbini, E. S., Seip, R., Iasemidis, L., O'Donnell, M., & Cain, C. A. (1992). Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation. In J. P. Morucci, R. Plonsey, S. Laxminarayan, & J. L. Coatrieux (Eds.), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 (pp. 352-353). [5761000] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 1). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IEMBS.1992.5761000

Cancer treatment with high intensity focused ultrasound : A combined therapy/imaging system for precision noninvasive lesion formation. / Ebbini, E. S.; Seip, R.; Iasemidis, L.; O'Donnell, M.; Cain, C. A.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. ed. / Jean Pierre Morucci; Robert Plonsey; Swamy Laxminarayan; Jean Louis Coatrieux. Institute of Electrical and Electronics Engineers Inc., 1992. p. 352-353 5761000 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ebbini, ES, Seip, R, Iasemidis, L, O'Donnell, M & Cain, CA 1992, Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation. in JP Morucci, R Plonsey, S Laxminarayan & JL Coatrieux (eds), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992., 5761000, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 1, Institute of Electrical and Electronics Engineers Inc., pp. 352-353, 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992, Paris, France, 10/29/92. https://doi.org/10.1109/IEMBS.1992.5761000

Ebbini ES, Seip R, Iasemidis L, O'Donnell M, Cain CA. Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation. In Morucci JP, Plonsey R, Laxminarayan S, Coatrieux JL, editors, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. Institute of Electrical and Electronics Engineers Inc. 1992. p. 352-353. 5761000. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.1992.5761000

Ebbini, E. S. ; Seip, R. ; Iasemidis, L. ; O'Donnell, M. ; Cain, C. A. / Cancer treatment with high intensity focused ultrasound : A combined therapy/imaging system for precision noninvasive lesion formation. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. editor / Jean Pierre Morucci ; Robert Plonsey ; Swamy Laxminarayan ; Jean Louis Coatrieux. Institute of Electrical and Electronics Engineers Inc., 1992. pp. 352-353 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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abstract = "A system with combined therapy/imaging capability for noninvasive lesion formation in tissue using high-intensity focused ultrasound will be presented. The system combines a highly focused therapeutic device with an imaging transducer for monitoring the treated volume in realtime using signal processing algorithms of ultrasound radio frequency (RF) echo data. Preliminary results indicate that it is feasible to distinguish between reversible and irreversible change in the state of the tissue due to high-intensity focused ultrasound. An autoregressive model has been assumed for processing echo data from the treated region. The reflection coefficients for a low-order AR model are calculated from A-line data taken during the treatment (every 1 to 2 seconds). The contours of the reflection coefficients can be used to distinguish between reversible and irreversible change in the state of the tissue. Noninvasive quantitative measures of thresholds for irreversible tissue damage based on the AR reflection coefficients are currently being investigated. Experimental results from our investigation will be presented. In addition, a review of the current status of research on tissue ablation using high-intensity focused ultrasound will be given.",

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Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation

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