Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation

E. S. Ebbini, R. Seip, L. Iasemidis, M. O'Donnell, C. A. Cain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A system with combined therapy/imaging capability for noninvasive lesion formation in tissue using high-intensity focused ultrasound will be presented. The system combines a highly focused therapeutic device with an imaging transducer for monitoring the treated volume in realtime using signal processing algorithms of ultrasound radio frequency (RF) echo data. Preliminary results indicate that it is feasible to distinguish between reversible and irreversible change in the state of the tissue due to high-intensity focused ultrasound. An autoregressive model has been assumed for processing echo data from the treated region. The reflection coefficients for a low-order AR model are calculated from A-line data taken during the treatment (every 1 to 2 seconds). The contours of the reflection coefficients can be used to distinguish between reversible and irreversible change in the state of the tissue. Noninvasive quantitative measures of thresholds for irreversible tissue damage based on the AR reflection coefficients are currently being investigated. Experimental results from our investigation will be presented. In addition, a review of the current status of research on tissue ablation using high-intensity focused ultrasound will be given.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
EditorsJean Pierre Morucci, Robert Plonsey, Swamy Laxminarayan, Jean Louis Coatrieux
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages352-353
Number of pages2
ISBN (Electronic)0780307852
DOIs
StatePublished - Jan 1 1992
Externally publishedYes
Event14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 - Paris, France
Duration: Oct 29 1992Nov 1 1992

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume1
ISSN (Print)1557-170X

Conference

Conference14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
CountryFrance
CityParis
Period10/29/9211/1/92

Fingerprint Dive into the research topics of 'Cancer treatment with high intensity focused ultrasound: A combined therapy/imaging system for precision noninvasive lesion formation'. Together they form a unique fingerprint.

Cite this