@inproceedings{000e965caff444b1b9b0b5631c7568ac,
title = "Cancer stem cells: Potential target for anti-cancer nanomedicines",
abstract = "The recently revived Cancer Stem Cell (CSC) hypothesis adds a new and important dimension to the development of anti-cancer therapeutics. Evidences suggest that the drug resistant CSCs contribute to cancer progression, recurrence and metastasis and are responsible for the failure of conventional anti-cancer treatments. In this chapter, the concept, the biological/functional properties and therapeutic implications of CSCs are covered. Furthermore, design and approaches of nanomedicines for targeting CSCs are discussed. In particular, the CSC inhibitory effect of a nanosized HPMA (N-(2-hydroxypropyl) methacrylamide) copolymer-based cyclopamine delivery system towards prostate CSCs is described.",
author = "Yan Zhou and Jiyuan Yang and Jind{\v r}ich Kope{\v c}ek",
year = "2013",
month = jul,
day = "8",
doi = "10.1021/bk-2013-1135.ch009",
language = "English (US)",
isbn = "9780841227989",
series = "ACS Symposium Series",
publisher = "American Chemical Society",
pages = "127--149",
booktitle = "Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications",
address = "United States",
}
