Cancer risk among patients with cystic fibrosis

Joseph P Neglia, Catherine L. Wielinski, Warren J. Warwick

Research output: Contribution to journalArticlepeer-review

34 Scopus citations
Original languageEnglish (US)
Pages (from-to)764-766
Number of pages3
JournalThe Journal of pediatrics
Issue number5
StatePublished - Nov 1991

Bibliographical note

Funding Information:
Seven hundred twelve patients with CF were included in this retrospective cohort. At the time of this analysis, 154 Supported by funds from the Childrens Cancer Research Fund of the University of Minnesota and the Cystic Fibrosis Foundation. Dr. Neglia is a recipient of National Cancer Institute Clinical Investigator Award CA 01240. Submitted for publication Jan. 8, 1991; accepted May 17, 1991. Reprint requests: Joseph P. Neglia, MD, Box 484 UMHC, Harvard St. at E. River Rd., Minneapolis, MN 55455. 9/22/31045 of the patients were known to be dead and 348 were alive and in active follow-up; 210 patients had been transferred to another institution or lost to follow-up. Ages in the cohort at analysis ranged from 1 month to 51 years (median 13.8 years). Two cancers were identified. The first case was that of a stage I seminoma that occurred in a 32-year-old man. The second was in a 10-year-old boy who had clonus and hyper-reflexia of the lower extremities; an intraspinal high-grade astrocytoma was found at laminectomy. At the time of analysis this cohort had accrued 10,622 person-years at risk. Application of the incidence rates of

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