Cancer outlier differential gene expression detection

Baolin Wu

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


We study statistical methods to detect cancer genes that are over- or down-expressed in some but not all samples in a disease group. This has proven useful in cancer studies where oncogenes are activated only in a small subset of samples. We propose the outlier robust t-statistic (ORT), which is intuitively motivated from the t-statistic, the most commonly used differential gene expression detection method. Using real and simulation studies, we compare the ORT to the recently proposed cancer outlier profile analysis (Tomlins and others, 2005) and the outlier sum statistic of Tibshirani and Hastie (2006). The proposed method often has more detection power and smaller false discovery rates. Supplementary information can be found at ∼baolin/research/ort.html.

Original languageEnglish (US)
Pages (from-to)566-575
Number of pages10
Issue number3
StatePublished - Jul 2007


  • Cancer outlier profile analysis
  • Differential gene expression detection
  • Microarray
  • Robust
  • T-statistic


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