Cancer negatively impacts on sexual function in adolescents and young adults: The AYA HOPE study

Lena Wettergren, Erin E. Kent, Sandra A. Mitchell, Brad Zebrack, Charles F. Lynch, Mara B. Rubenstein, Theresa H M Keegan, Xiao Cheng Wu, Helen M. Parsons, Ashley Wilder Smith

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Objective: This cohort study examined the impact of cancer on sexual function and intimate relationships in adolescents and young adults (AYAs). We also explored factors predicting an increased likelihood that cancer had negatively affected these outcomes. Methods: Participants (n = 465, ages 15–39) in the Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) study completed two surveys approximately 1 and 2 years post-cancer diagnosis. We used multivariable logistic regression to determine factors negatively affected by perceptions of sexual function at 2 years post-diagnosis. Results: Forty-nine percent of AYAs reported negative effects on sexual function at 1 year post-cancer diagnosis and 70% of those persisted in their negative perceptions 2 years after diagnosis. Those reporting a negative impact at 2 years were more likely to be 25 years or older (OR, 2.53; 95% CI, 1.44–4.42), currently not raising children (OR, 1.81; 95% CI, 1.06–3.08), experiencing fatigue (OR, 0.99; 95% CI, 0.975–0.998) and more likely to report that their diagnosis has had a negative effect on physical appearance (OR, 3.08; 95% CI, 1.97–4.81). Clinical factors and mental health were not significant predictors of negative effects on sexual function. Conclusions: Many AYAs diagnosed with cancer experience a persistent negative impact on sexual life up to 2 years following diagnosis. The findings underscore the need to develop routine protocols to assess sexual function in AYAs with cancer and to provide comprehensive management in the clinical setting.

Original languageEnglish (US)
Pages (from-to)1632-1639
Number of pages8
Issue number10
StatePublished - Oct 2017

Bibliographical note

Funding Information:
This work was supported by National Cancer Institute at the National Institutes of Health. The Swedish Childhood Cancer Foundation and the Cancer Research Foundations of Radiumhemmet also supported the study.

Publisher Copyright:
Copyright © 2016 John Wiley & Sons, Ltd.


  • cancer
  • complications
  • oncology
  • sexuality
  • survivors
  • young adults


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